INT271733

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Context Info
Confidence 0.65
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.91
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Psmc1) cytoplasm (Psmc1)
Anatomy Link Frequency
muscle 1
Psmc1 (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 1 68.32 Quite High
Inflammation 1 7.84 Low Low
addiction 6 6.56 Low Low
Neurotransmitter 14 5.00 Very Low Very Low Very Low
Glutamate 8 5.00 Very Low Very Low Very Low
Action potential 6 5.00 Very Low Very Low Very Low
Hippocampus 5 5.00 Very Low Very Low Very Low
long-term potentiation 4 5.00 Very Low Very Low Very Low
Spinal cord 4 5.00 Very Low Very Low Very Low
midbrain 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Channelopathies 34 98.48 Very High Very High Very High
Hypokalemic Periodic Paralysis 58 95.36 Very High Very High Very High
Disease 42 75.84 Quite High
Neurodegenerative Disease 8 75.68 Quite High
Motor Neuron Diseases 1 74.24 Quite High
Creutzfeldt Jakob Disease 2 71.52 Quite High
Brain Hemorrhage 1 68.32 Quite High
Aging 11 67.48 Quite High
Neurological Disease 1 57.56 Quite High
Targeted Disruption 22 53.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Intriguingly, as knockdown of Rpt2/PSMC1 expression leads to a specific impairment of 26S proteasome activity, while activity of the 20S proteasome is unaffected, neurodegeneration can be conclusively attributed to dysfunction of the 26S proteasome [31].
Gene_expression (expression) of PSMC1
1) Confidence 0.65 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2690827 Disease Relevance 1.10 Pain Relevance 0.03
The location of other positive charges in the S4 domains is indicated as black circles (plus sign)
Gene_expression (domains) of S4
2) Confidence 0.10 Published 2010 Journal Pflugers Arch Section Body Doc Link PMC2883925 Disease Relevance 0.26 Pain Relevance 0
-subunit point mutations, also outside of the S4 helices, are known to cause different muscle channelopathies (for review, see [39]) but as in Cav1.1 ?
Gene_expression (helices) of S4 in muscle associated with channelopathies
3) Confidence 0.08 Published 2010 Journal Pflugers Arch Section Body Doc Link PMC2883925 Disease Relevance 0.55 Pain Relevance 0

General Comments

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