INT271737

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Context Info
Confidence 0.03
First Reported 2009
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.46
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Psmb10) cell morphogenesis (Psmb10) nucleus (Psmb10)
cytoplasm (Psmb10)
Psmb10 (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 11 5.00 Very Low Very Low Very Low
midbrain 5 5.00 Very Low Very Low Very Low
Spinal cord 4 5.00 Very Low Very Low Very Low
Central nervous system 3 5.00 Very Low Very Low Very Low
Hippocampus 3 5.00 Very Low Very Low Very Low
Catecholamine 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Thalamus 2 5.00 Very Low Very Low Very Low
Glutamate 2 5.00 Very Low Very Low Very Low
Locus ceruleus 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Parkinson's Disease 49 92.32 High High
Disease 102 91.52 High High
Targeted Disruption 20 82.00 Quite High
Aging 13 75.00 Quite High
Teratocarcinoma 1 24.56 Low Low
Death 14 13.12 Low Low
Stress 17 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 12 5.00 Very Low Very Low Very Low
Apoptosis 8 5.00 Very Low Very Low Very Low
Toxicity 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Covalent linkage of ubiquitin regulates the function and, ultimately, the degradation of many proteins by the ubiquitin-proteasome system (UPS).
Regulation (regulates) of proteasome
1) Confidence 0.03 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2690827 Disease Relevance 0.22 Pain Relevance 0
Recently, Endo and coworkers showed that a dysfunction of the mitochondrial import system without ATP alterations may up-regulate proteasome activity (Endo et al., 2009).
Spec (may) Regulation (regulate) of proteasome
2) Confidence 0.00 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2890153 Disease Relevance 0.24 Pain Relevance 0

General Comments

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