INT271764

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.27
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.16
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (Cnga1) cytoplasm (Cnga1)
Anatomy Link Frequency
optic nerve 1
Cnga1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 2 95.44 Very High Very High Very High
Central nervous system 4 90.16 High High
qutenza 1 83.28 Quite High
HCN1 6 68.96 Quite High
long-term potentiation 6 64.64 Quite High
depression 4 61.64 Quite High
Action potential 3 45.24 Quite Low
Glutamate receptor 2 22.24 Low Low
GABAergic 2 16.56 Low Low
tetrodotoxin 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pain 2 95.44 Very High Very High Very High
Depression 4 61.64 Quite High
Decapitation 2 5.00 Very Low Very Low Very Low
Aging 2 5.00 Very Low Very Low Very Low
Dislocations 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
An interaction with HCN channels may also contribute to the participation of the NO-cGMP pathway in certain clinical conditions, such as pain (Levy & Zochodne, 2004; Jiang et al., 2008).



HCN Binding (interaction) of associated with pain
1) Confidence 0.27 Published 2010 Journal The European Journal of Neuroscience Section Body Doc Link PMC2955965 Disease Relevance 0.16 Pain Relevance 0.23
In optic nerve axons, hyperpolarization-activated cyclic nucleotide-modulated cation (HCN) channels, which bind cGMP or cAMP directly, were recently suggested to be a target.
HCN Binding (bind) of in optic nerve
2) Confidence 0.20 Published 2010 Journal The European Journal of Neuroscience Section Abstract Doc Link PMC2955965 Disease Relevance 0 Pain Relevance 0
Residue E365 in human CNG1 (corresponding to E363 in bovine) was identified as a critical binding site for Ca2+ ions that can reduce selectivity for monovalent cations in a voltage dependent fashion [29]–[31].
CNG1 Binding (binding) of
3) Confidence 0.08 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2690840 Disease Relevance 0 Pain Relevance 0.15

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox