INT271775

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Context Info
Confidence 0.69
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 6
Disease Relevance 5.16
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (Ache) extracellular space (Ache) extracellular region (Ache)
cell adhesion (Ache) Golgi apparatus (Ache) plasma membrane (Ache)
Anatomy Link Frequency
neuronal 6
hippocampus 3
brain 2
cortex 1
Ache (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 16 98.44 Very High Very High Very High
Thalamus 4 74.04 Quite High
ischemia 8 65.84 Quite High
Spinal cord 40 21.24 Low Low
Dopamine 32 5.00 Very Low Very Low Very Low
Multiple sclerosis 24 5.00 Very Low Very Low Very Low
Inflammation 22 5.00 Very Low Very Low Very Low
Demyelination 16 5.00 Very Low Very Low Very Low
potassium channel 12 5.00 Very Low Very Low Very Low
Neuritis 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 46 99.60 Very High Very High Very High
Cognitive Disorder 60 98.76 Very High Very High Very High
Stress 16 97.96 Very High Very High Very High
Disease 310 87.96 High High
Vomiting 4 74.60 Quite High
Toxicity 6 73.88 Quite High
Cv Unclassified Under Development 8 65.84 Quite High
Stroke 8 64.88 Quite High
Atrophy 28 63.00 Quite High
Death 14 61.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We observed that the elevated expression of AChE by scopolamine in both the cortex and hippocampus was decreased by the treatment with 4-O-methylhonokiol (data not shown).
Positive_regulation (elevated) of Gene_expression (expression) of AChE in hippocampus associated with hippocampus
1) Confidence 0.69 Published 2009 Journal J Nat Med Section Body Doc Link PMC2690856 Disease Relevance 0.51 Pain Relevance 0.08
We observed that the elevated expression of AChE by scopolamine in both the cortex and hippocampus was decreased by the treatment with 4-O-methylhonokiol (data not shown).
Positive_regulation (elevated) of in cortex Gene_expression (expression) of AChE in hippocampus associated with hippocampus
2) Confidence 0.24 Published 2009 Journal J Nat Med Section Body Doc Link PMC2690856 Disease Relevance 0.51 Pain Relevance 0.08
Prolonged AChE overexpression occurs in the mammalian brain under psychological stress [62], and various studies provide evidence that such stress can induce BBB disruption [84, 89] via yet unknown mechanisms.
Positive_regulation (overexpression) of Gene_expression (overexpression) of AChE in brain associated with stress
3) Confidence 0.23 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923365 Disease Relevance 0.97 Pain Relevance 0.06
To approach this question, Beeri and colleagues [7] used transgenic mice with neuronal over-expression of synaptic acetylcholinesterase (AChE-S) of human origin.
Positive_regulation (over) of Gene_expression (expression) of AChE in neuronal associated with targeted disruption
4) Confidence 0.16 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923365 Disease Relevance 1.06 Pain Relevance 0.04
To approach this question, Beeri and colleagues [7] used transgenic mice with neuronal over-expression of synaptic acetylcholinesterase (AChE-S) of human origin.
Positive_regulation (over) of Gene_expression (over) of synaptic acetylcholinesterase in neuronal associated with targeted disruption
5) Confidence 0.14 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923365 Disease Relevance 1.05 Pain Relevance 0.04
To approach this question, Beeri and colleagues [7] used transgenic mice with neuronal over-expression of synaptic acetylcholinesterase (AChE-S) of human origin.
Positive_regulation (over) of Gene_expression (-) of synaptic acetylcholinesterase in neuronal associated with targeted disruption
6) Confidence 0.14 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923365 Disease Relevance 1.05 Pain Relevance 0.04

General Comments

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