INT271855

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Context Info
Confidence 0.06
First Reported 2009
Last Reported 2009
Negated 2
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 11.07
Pain Relevance 0.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
tonsil 3
lymphoid tissues 2
feces 1
medulla 1
brain 1
PR@ (Homo sapiens)
Pain Link Frequency Relevance Heat
medulla 80 99.68 Very High Very High Very High
anesthesia 10 93.20 High High
headache 13 90.24 High High
Bioavailability 3 54.16 Quite High
antagonist 5 28.56 Quite Low
abdominal pain 6 5.00 Very Low Very Low Very Low
peripheral neuropathy 4 5.00 Very Low Very Low Very Low
chemokine 4 5.00 Very Low Very Low Very Low
corticosteroid 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypersensitivity 9 99.80 Very High Very High Very High
Chronic Wasting Disease 820 99.62 Very High Very High Very High
Infection 224 99.20 Very High Very High Very High
Urticaria 1 98.64 Very High Very High Very High
Pressure And Volume Under Development 1 98.20 Very High Very High Very High
Bronchospasm 1 97.56 Very High Very High Very High
Liver Disease 4 95.32 Very High Very High Very High
Congenital Anomalies 11 92.24 High High
Dysesthesia 4 91.24 High High
Headache 13 90.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PR interval prolongation and allergic reactions including urticaria, angioedema, and bronchospasm have also been reported.9

Saquinavir (InviraseĀ®)

Gene_expression (prolongation) of PR associated with urticaria, pressure and volume under development, bronchospasm and hypersensitivity
1) Confidence 0.06 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2701488 Disease Relevance 1.60 Pain Relevance 0.25
After oral inoculation with CWD+ brain homogenate, PrPCWD was detected in the tonsil of 4 of 4 inoculated deer at either 6 (n?
Gene_expression (detected) of PrPCWD in tonsil associated with chronic wasting disease
2) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2691594 Disease Relevance 0.96 Pain Relevance 0
We report no detection of PrPCWD in the obex or lymphoid tissues of deer with either G/G or G/S polymorphisms at 19 mo pi.
Neg (no) Gene_expression (detection) of PrPCWD in lymphoid tissues
3) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2691594 Disease Relevance 0.98 Pain Relevance 0
In 3 animals, however, (one each in the blood, saliva and positive control inoculation cohorts) in which previous tonsil biopsies had been negative, PrPCWD was detected in tonsil, retropharyngeal lymphoid tissues and brain collected at necropsy (Fig. 1).
Gene_expression (detected) of PrPCWD in lymphoid tissues
4) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2691594 Disease Relevance 0.78 Pain Relevance 0.04
Previous studies have postulated that environmental contamination by excreta from infected cervids seems the most plausible explanation for the dissemination of CWD [70], yet at 19 months pi we were not able to detect PrPCWD in the three deer inoculated with urine and feces.
Gene_expression (detect) of PrPCWD in urine associated with chronic wasting disease
5) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2691594 Disease Relevance 0.97 Pain Relevance 0
At 19 months pi, when the cohort was necropsied, all three deer were CWD+, as indicated by detection of PrPCWD in the medulla oblongata at the level of the obex (medulla at obex) and in lymphoid tissue (Fig. 2).


Gene_expression (detection) of PrPCWD in medulla associated with medulla and chronic wasting disease
6) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2691594 Disease Relevance 1.22 Pain Relevance 0.10
PrPCWD was detected in tonsil of 1 of the 3 inoculated deer at 12 months pi, but not at earlier time points.
Neg (not) Gene_expression (detected) of PrPCWD in tonsil
7) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2691594 Disease Relevance 1.18 Pain Relevance 0.09
Efficient transmission, as evidenced by tonsillar lymphoid PrPCWD detection, was seen in as little as 15 months post initial exposure.
Gene_expression (detection) of PrPCWD
8) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2691594 Disease Relevance 0.98 Pain Relevance 0
We assume that the time until appearance of PrPCWD in tonsil is an underestimate due to the inherent variability in prion deposition kinetics [36] and the logistical limitations of tonsil biopsies, which require general anesthesia.
Gene_expression (appearance) of PrPCWD in tonsil associated with anesthesia
9) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2691594 Disease Relevance 0.66 Pain Relevance 0.09
Previous studies have postulated that environmental contamination by excreta from infected cervids seems the most plausible explanation for the dissemination of CWD [70], yet at 19 months pi we were not able to detect PrPCWD in the three deer inoculated with urine and feces.
Gene_expression (detect) of PrPCWD in feces associated with chronic wasting disease
10) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2691594 Disease Relevance 0.97 Pain Relevance 0
In 3 animals, however, (one each in the blood, saliva and positive control inoculation cohorts) in which previous tonsil biopsies had been negative, PrPCWD was detected in tonsil, retropharyngeal lymphoid tissues and brain collected at necropsy (Fig. 1).
Gene_expression (detected) of PrPCWD in brain
11) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2691594 Disease Relevance 0.78 Pain Relevance 0.04

General Comments

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