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Context Info
Confidence 0.01
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.30
Pain Relevance 1.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL1RN, IL1B) extracellular region (IL1RN, IL1B) aging (IL1B)
intracellular (IL1RN) cell-cell signaling (IL1B) cytoplasm (IL1RN)
IL1RN (Homo sapiens)
IL1B (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 2 100.00 Very High Very High Very High
anakinra 7 99.36 Very High Very High Very High
Infliximab 18 93.40 High High
Etanercept 18 92.80 High High
rheumatoid arthritis 63 91.84 High High
Adalimumab 8 90.92 High High
methotrexate 39 85.76 High High
metalloproteinase 3 77.68 Quite High
Arthritis 5 50.36 Quite High
spinal inflammation 1 49.40 Quite Low
Disease Link Frequency Relevance Heat
Heart Rate Under Development 3 97.92 Very High Very High Very High
Autoimmune Disease 3 96.88 Very High Very High Very High
Demyelinating Disease 3 95.60 Very High Very High Very High
Mycobacterial Infection 3 95.00 High High
Opportunistic Infections 4 94.44 High High
Rheumatoid Arthritis 64 91.84 High High
Lymphatic System Cancer 5 57.28 Quite High
Pneumonia 1 53.92 Quite High
Infection 2 51.92 Quite High
Seronegative Spondarthritis 1 50.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Anakinra is a recombinant form of human IL-1RA that acts as an antagonist to the biological activity of IL-1 by competitively inhibiting the binding of IL-1 to its cell membrane receptor, thus blocking cell signaling (Fig. 2d).
IL-1RA Negative_regulation (inhibiting) of IL-1 Binding (binding) of associated with anakinra and antagonist
1) Confidence 0.01 Published 2008 Journal Current Genomics Section Body Doc Link PMC2691664 Disease Relevance 1.30 Pain Relevance 1.01

General Comments

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