INT271903

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Context Info
Confidence 0.14
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.47
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

kinase activity (Skp2)
Skp2 (Mus musculus)
Pain Link Frequency Relevance Heat
cerebral cortex 2 5.00 Very Low Very Low Very Low
transdermal 2 5.00 Very Low Very Low Very Low
adenocard 2 5.00 Very Low Very Low Very Low
Angina 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 40 91.28 High High
Stress 4 57.52 Quite High
Tuberous Sclerosis 22 50.00 Quite Low
Hamartoma 16 45.04 Quite Low
Death 8 43.64 Quite Low
Apoptosis 6 41.12 Quite Low
Disease 42 5.00 Very Low Very Low Very Low
Angiomyolipoma 24 5.00 Very Low Very Low Very Low
Lymphangioleiomyomatosis 22 5.00 Very Low Very Low Very Low
Convulsion 18 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Skp2 is the F-box protein, which together with other proteins forms an SCF-type E3 ubiquitin ligase complex, whose task is to target p27 for degradation by the proteasome [95, 96].
Positive_regulation (target) of Protein_catabolism (degradation) of Skp2
1) Confidence 0.14 Published 2008 Journal Current Genomics Section Body Doc Link PMC2691673 Disease Relevance 0.12 Pain Relevance 0
However, binding of tuberin to p27 sequesters p27 from Skp2 accompanied by a stabilization of the p27 interaction with cdk2, and hence, Skp2-induced p27 degradation and cell cycle progression is abolished by tuberin’s protective binding to p27.
Positive_regulation (induced) of Protein_catabolism (degradation) of Skp2
2) Confidence 0.14 Published 2008 Journal Current Genomics Section Body Doc Link PMC2691673 Disease Relevance 0.35 Pain Relevance 0

General Comments

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