INT271907

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Context Info
Confidence 0.09
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 0.67
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitosis (Rps6) structural constituent of ribosome (Rps6) ribosome (Rps6)
nucleolus (Rps6) nucleus (Rps6) cytoplasm (Rps6)
Rps6 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 2 28.48 Quite Low
Clonidine 14 5.00 Very Low Very Low Very Low
Hippocampus 6 5.00 Very Low Very Low Very Low
agonist 4 5.00 Very Low Very Low Very Low
medulla 4 5.00 Very Low Very Low Very Low
cerebral cortex 3 5.00 Very Low Very Low Very Low
palliative 2 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
antinociception 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 121 90.08 High High
Cancer 106 77.12 Quite High
Pancreatic Cancer 40 75.32 Quite High
Hamartoma 8 57.64 Quite High
Death 20 56.24 Quite High
Apoptosis 3 52.08 Quite High
Tuberous Sclerosis 11 50.00 Quite Low
Toxicity 10 50.00 Quite Low
Tremor 22 35.04 Quite Low
Aneuploidy 2 28.80 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
S6 ribosomal protein phsophorylation at Ser236/236 and Ser240/244 was notably greater inhibited with combination treatment all the 3 models.
Phosphorylation (phsophorylation) of S6 ribosomal protein
1) Confidence 0.09 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2955043 Disease Relevance 0.34 Pain Relevance 0
The combination treatment of RDEA119 and rapamycin produced the greatest decrease in Ser235/236 and Ser240/244 phosphorylated S6 ribosomal protein in all the 3 models.
Phosphorylation (phosphorylated) of S6 ribosomal protein
2) Confidence 0.09 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2955043 Disease Relevance 0 Pain Relevance 0
Unlike rapamycin, which has previously been identified as a possible therapeutic due to its upregulation of autophagy, rilmenidine had no effect on phosphorylation of p70 S6 kinase (Fig. 1G), S6 protein (Fig. 1H) or 4E-BP1 (Fig. 1I), all downstream substrates of mTOR kinase activity.


Phosphorylation (phosphorylation) of S6 protein
3) Confidence 0.06 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2865373 Disease Relevance 0.16 Pain Relevance 0
The primary antibodies used were anti-polyglutamine (1C2, Chemicon), anti-LC3 (Novus), anti-phosphorylated and total 4E-BP1, S6 kinase and S6 protein (all Cell Signaling), anti-tubulin and anti-actin (Sigma).
Phosphorylation (phosphorylated) of S6 protein
4) Confidence 0.03 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2865373 Disease Relevance 0 Pain Relevance 0
Inhibition of the GAP function of TSC2 shifts the balance of its substrate Rheb to the Rheb-GTP form, which activates the mTOR protein and ultimately leads to phosphorylation of ribosomal protein S6 and 4E-BP1 resulting in increased protein synthesis and cell proliferation.
Phosphorylation (phosphorylation) of ribosomal protein S6
5) Confidence 0.03 Published 2008 Journal Current Genomics Section Body Doc Link PMC2691673 Disease Relevance 0.17 Pain Relevance 0

General Comments

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