INT271915

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Context Info
Confidence 0.36
First Reported 2007
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 6.44
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Pkd1) plasma membrane (Pkd1) nucleus (Pkd1)
cilium (Pkd1)
Anatomy Link Frequency
kidney 2
liver 1
Pkd1 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 36 5.00 Very Low Very Low Very Low
Mechanosensation 12 5.00 Very Low Very Low Very Low
Somatostatin 12 5.00 Very Low Very Low Very Low
fibrosis 8 5.00 Very Low Very Low Very Low
antagonist 6 5.00 Very Low Very Low Very Low
Mechanotransduction 3 5.00 Very Low Very Low Very Low
Kinase C 3 5.00 Very Low Very Low Very Low
Angina 3 5.00 Very Low Very Low Very Low
adenocard 3 5.00 Very Low Very Low Very Low
abdominal pain 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 23 100.00 Very High Very High Very High
Cyst 129 99.28 Very High Very High Very High
Disease 165 98.52 Very High Very High Very High
Autosomal Dominant Polycystic Kidney 116 97.58 Very High Very High Very High
Pancreatic Cyst 3 97.00 Very High Very High Very High
Cv Unclassified Under Development 20 94.64 High High
Left Ventricular Hypertrophy 15 93.28 High High
Calcification 1 92.56 High High
Pathologic Constriction 1 91.84 High High
Cystic Kidney Diseases 25 91.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Likely, patients with a deletion that disrupts the PKD1 and TSC2 genes are usually identified as TSC patients.
Negative_regulation (disrupts) of PKD1
1) Confidence 0.36 Published 2008 Journal Current Genomics Section Body Doc Link PMC2691673 Disease Relevance 0.61 Pain Relevance 0
While compounds 3 and 5 are structurally very close to PC1 and PC2, compound 4 is a guanine analog (Figure 3A).
Negative_regulation (close) of PC1
2) Confidence 0.34 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2858708 Disease Relevance 0.07 Pain Relevance 0
Five of the 27 unrelated patients studied by Sampson et al. [56] had multiple cysts in both kidneys, but no detectable disruption of PKD1.
Neg (no) Negative_regulation (disruption) of PKD1 associated with cyst
3) Confidence 0.27 Published 2008 Journal Current Genomics Section Body Doc Link PMC2691673 Disease Relevance 0.53 Pain Relevance 0
Mice with conditional inactivation of the Pkd1 gene develop kidney and liver cysts, but disease is too mild to be informative in preclinical testing [97].
Negative_regulation (inactivation) of Pkd1 gene in liver associated with cyst and disease
4) Confidence 0.26 Published 2007 Journal Cell Mol Life Sci Section Body Doc Link PMC2775119 Disease Relevance 1.05 Pain Relevance 0
A dozen different mouse models with targeted disruption of the Pkd1 gene have been created, including animals with conditional gene inactivation (reviewed in [96]).
Negative_regulation (disruption) of Pkd1 gene associated with targeted disruption
5) Confidence 0.26 Published 2007 Journal Cell Mol Life Sci Section Body Doc Link PMC2775119 Disease Relevance 1.01 Pain Relevance 0
Therefore, the cardiovascular complications seen in ADPKD patients begin to be recognized not only as a consequence of declining kidney function, but also as a defect due to the loss of polycystin-1 and/or polycystin-2 function in cardiovascular organs [31].

2.3.

Negative_regulation (loss) of polycystin-1 in kidney associated with autosomal dominant polycystic kidney
6) Confidence 0.25 Published 2011 Journal International Journal of Nephrology Section Body Doc Link PMC3017903 Disease Relevance 2.12 Pain Relevance 0
When cells were grown in minimal medium with increasing concentrations of PC1 and PC2, beta-galactosidase activity was clearly repressed in a dose-dependent manner suggesting a modulation of the guanine riboswitch gene regulation by both molecules.
Negative_regulation (repressed) of PC1
7) Confidence 0.15 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2858708 Disease Relevance 0 Pain Relevance 0
Mice with conditional inactivation of the Pkd1 gene develop kidney and liver cysts, but disease is too mild to be informative in preclinical testing [97].
Negative_regulation (inactivation) of Pkd1 gene in kidney associated with cyst and disease
8) Confidence 0.09 Published 2007 Journal Cell Mol Life Sci Section Body Doc Link PMC2775119 Disease Relevance 1.05 Pain Relevance 0

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