INT271917

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Context Info
Confidence 0.13
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 22
Disease Relevance 6.76
Pain Relevance 0.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Mtor) mitochondrion (Mtor) Golgi apparatus (Mtor)
endoplasmic reticulum (Mtor) nucleus (Mtor) kinase activity (Mtor)
Mtor (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 432 99.30 Very High Very High Very High
Kinase C 1 98.48 Very High Very High Very High
Inflammation 8 97.72 Very High Very High Very High
cerebral cortex 122 64.72 Quite High
fibrosis 15 52.32 Quite High
transdermal 2 5.20 Low Low
Clonidine 21 5.00 Very Low Very Low Very Low
anesthesia 16 5.00 Very Low Very Low Very Low
alcohol 12 5.00 Very Low Very Low Very Low
addiction 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 420 99.30 Very High Very High Very High
Stress 391 99.30 Very High Very High Very High
Hypoxia 72 98.76 Very High Very High Very High
Insulin Resistance 25 98.50 Very High Very High Very High
INFLAMMATION 8 97.72 Very High Very High Very High
Apoptosis 17 96.36 Very High Very High Very High
Muscular Atrophy 6 94.40 High High
Hypertrophy 3 91.80 High High
Targeted Disruption 33 89.12 High High
Hamartoma 16 83.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As2O3 inhibits phosphorylation of Akt, mTOR (mammalian target of rapamycin), and p70s6k
Phosphorylation (phosphorylation) of mTOR
1) Confidence 0.13 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2920914 Disease Relevance 0 Pain Relevance 0
Therefore, we investigated the effects of As2O3 on the phosphorylation of Akt and its downstream signals, mTOR and p70s6k, during myogenic differentiation.
Phosphorylation (phosphorylation) of mTOR
2) Confidence 0.13 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2920914 Disease Relevance 0 Pain Relevance 0
In the present study, we found that a submicromolar concentration of As2O3 significantly and dose-dependently decreased phosphorylation of Akt protein and its downstream targets, mTOR and p70s6k, during myogenic differentiation.
Phosphorylation (phosphorylation) of mTOR
3) Confidence 0.13 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2920914 Disease Relevance 0.56 Pain Relevance 0.06
form, whereas mTOR phosphorylation remained at control levels.
Phosphorylation (phosphorylation) of mTOR
4) Confidence 0.07 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0.29 Pain Relevance 0.04
The mTOR phosphorylation at Ser2448 (and Ser2481 autophosphorylation) and 4E-BP1 phosphorylation were restored during reperfusion and returned to control values.
Phosphorylation (phosphorylation) of mTOR
5) Confidence 0.07 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0.35 Pain Relevance 0.05
In addition, mTOR autophosphorylation at Ser2481 (24) was also decreased by ischemia (data not shown).
Phosphorylation (autophosphorylation) of mTOR associated with ischemia
6) Confidence 0.07 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0.36 Pain Relevance 0.05
The mTOR phosphorylation at Ser2448 (and Ser2481 autophosphorylation) and 4E-BP1 phosphorylation were restored during reperfusion and returned to control values.
Phosphorylation (phosphorylation) of mTOR
7) Confidence 0.07 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0.35 Pain Relevance 0.05
We found a significant decrease in Ser473 phosphorylation in ischemic stress that was related to the decreased mTOR phosphorylation at Ser2448.
Phosphorylation (phosphorylation) of mTOR associated with stress
8) Confidence 0.07 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0.10 Pain Relevance 0
The mTOR phosphorylation at Ser2448 (and Ser2481 autophosphorylation) and 4E-BP1 phosphorylation were restored during reperfusion and returned to control values.
Phosphorylation (phosphorylation) of mTOR
9) Confidence 0.06 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0.35 Pain Relevance 0.05
In a number of studies, long chain saturated fatty acids have been shown to induce insulin resistance by activation of pathways involved in inflammation that intersect with insulin resistance such as the Toll-like receptor 4 mediated activation of NF-kB, as well as hyperphosphorylation of protein kinases like mammalian target of rapamycin (mTOR), c-jun N-terminal kinase (JNK), and protein kinase C isoforms [20-22].
Phosphorylation (hyperphosphorylation) of mTOR associated with kinase c, inflammation and insulin resistance
10) Confidence 0.06 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2852377 Disease Relevance 0.66 Pain Relevance 0.10
Since phosphorylation of mTOR depends on KIT signaling in the imatinib-sensitive GISTs, RAD001 did not show any synergistic effect with imatinib in this setting.
Phosphorylation (phosphorylation) of mTOR
11) Confidence 0.05 Published 2009 Journal World J Surg Oncol Section Body Doc Link PMC2749031 Disease Relevance 0.72 Pain Relevance 0
RAIP motif has a direct effect on mTOR-dependent phosphorylation of Thr36/Thr45 sites, whereas TOS motif primarily affects phosphorylation of Thr69 and also Ser64 (9, 23).
Phosphorylation (phosphorylation) of mTOR
12) Confidence 0.05 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0.08 Pain Relevance 0
No significant changes were found in mTOR and Akt phosphorylation in the R3d group with respect to the SHC3d control.



Phosphorylation (phosphorylation) of mTOR
13) Confidence 0.05 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0.30 Pain Relevance 0.08
I15 induced a significant decrease in mTOR phosphorylation at the Ser2448 site, which was restored to control levels upon reperfusion (R30 or R3d), with the exception of CA1 SHC that had increased Ser2448 phosphorylation (Fig. 6; supplemental Fig.
Phosphorylation (phosphorylation) of mTOR associated with ischemia
14) Confidence 0.05 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0.35 Pain Relevance 0.12
Finally, we studied the phosphorylation of mTOR at Ser2448, a residue that is correlated with kinase activity (24), and the activity of the upstream effector of mTORC1, the serine/threonine-protein kinase Akt (also named protein kinase B), through phosphorylation at Thr308 and Ser473 (25).
Phosphorylation (phosphorylation) of mTOR
15) Confidence 0.05 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0.33 Pain Relevance 0.10
In addition, activation of mTORC1 is correlated with the phosphorylation of mTOR at Ser2448 in a PI3-kinase/Akt signaling-dependent fashion (24).
Phosphorylation (phosphorylation) of mTOR
16) Confidence 0.05 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0.31 Pain Relevance 0.03
Our results showed that inhibition of mTORC1 activity was induced by ischemic stress, which was confirmed by a significant decrease in 4E-BP1 and mTOR-Ser2448 phosphorylation.
Phosphorylation (phosphorylation) of mTOR associated with stress
17) Confidence 0.05 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0.35 Pain Relevance 0.04
In order to examine potential mechanisms by which antioxidants may influence autophagy, we examined their effect on the mTOR pathway, a classical negative regulator of autophagy, by looking for changes in the phosphorylation status of an mTOR kinase substrate 4E binding protein 1 (4E-BP1) and a protein dependent on mTOR substrate kinase activity, ribosomal protein S6 (S6).
Phosphorylation (phosphorylation) of mTOR
18) Confidence 0.02 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2916709 Disease Relevance 0.13 Pain Relevance 0
(A) Vitamin E increases phosphorylation of mTOR substrates.
Phosphorylation (phosphorylation) of mTOR
19) Confidence 0.02 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2916709 Disease Relevance 0 Pain Relevance 0
(B) NAC decreases phosphorylation of mTOR substrates.
Phosphorylation (phosphorylation) of mTOR
20) Confidence 0.02 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2916709 Disease Relevance 0 Pain Relevance 0

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