INT271921

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Context Info
Confidence 0.26
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.19
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Tsc2) signal transduction (Tsc2) Golgi apparatus (Tsc2)
nucleus (Tsc2) protein complex (Tsc2) cytoplasm (Tsc2)
Tsc2 (Mus musculus)
Pain Link Frequency Relevance Heat
carbamazepine 2 5.00 Very Low Very Low Very Low
Clonidine 2 5.00 Very Low Very Low Very Low
Substantia nigra 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
cerebral cortex 1 5.00 Very Low Very Low Very Low
transdermal 1 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
Angina 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Tuberous Sclerosis 13 92.72 High High
Apoptosis 13 87.64 High High
Stress 10 82.08 Quite High
Cancer 28 77.68 Quite High
Sprains And Strains 3 67.44 Quite High
Starvation 12 59.00 Quite High
Renal Cancer 3 57.12 Quite High
Dna Damage 2 53.76 Quite High
Disease 51 48.32 Quite Low
Adenoma 2 6.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Loss of tuberin is accompanied by the loss of OGG1 contributing to tumourgenesis [99].


Negative_regulation (Loss) of tuberin
1) Confidence 0.26 Published 2008 Journal Current Genomics Section Body Doc Link PMC2691673 Disease Relevance 0.67 Pain Relevance 0
Since TSC1/TSC2 acts as the GTPase-activating protein (GAP) for the Ras-family GTP binding protein, Rheb, which directly binds and activates mTOR [17], loss of TSC1/TSC2 activity results in mTOR activation.
Negative_regulation (loss) of TSC2
2) Confidence 0.22 Published 2010 Journal Seminars in Cell & Developmental Biology Section Body Doc Link PMC2938570 Disease Relevance 0.32 Pain Relevance 0
Phosphorylation of TSC2 by these kinases leads to the disruption of the heterodimer with TSC1, resulting in loss of TSC1/TSC2 activity.
Negative_regulation (loss) of TSC2
3) Confidence 0.22 Published 2010 Journal Seminars in Cell & Developmental Biology Section Body Doc Link PMC2938570 Disease Relevance 0.20 Pain Relevance 0

General Comments

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