INT271929

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Context Info
Confidence 0.11
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.69
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Psmd9)
Psmd9 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 65 97.64 Very High Very High Very High
agonist 2 62.80 Quite High
Inflammation 43 50.00 Quite Low
Arthritis 64 5.00 Very Low Very Low Very Low
cytokine 15 5.00 Very Low Very Low Very Low
methotrexate 4 5.00 Very Low Very Low Very Low
cerebral cortex 3 5.00 Very Low Very Low Very Low
transdermal 3 5.00 Very Low Very Low Very Low
Angina 3 5.00 Very Low Very Low Very Low
adenocard 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 72 98.14 Very High Very High Very High
Rheumatoid Arthritis 65 97.64 Very High Very High Very High
Apoptosis 54 88.04 High High
Stress 6 79.12 Quite High
Medulloblastoma 1 73.32 Quite High
Tuberous Sclerosis 33 50.00 Quite Low
Hamartoma 24 39.72 Quite Low
Death 15 38.32 Quite Low
Necrosis 5 24.96 Low Low
Disease 66 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Of note, TRAIL was shown to induce the breakdown of p21 and p27 that were both caspase-dependent, but independent of ERK 1/2, p38 kinase and PI3K/Akt activity.
Protein_catabolism (breakdown) of p27
1) Confidence 0.11 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2842969 Disease Relevance 0.73 Pain Relevance 0.21
However, binding of tuberin to p27 sequesters p27 from Skp2 accompanied by a stabilization of the p27 interaction with cdk2, and hence, Skp2-induced p27 degradation and cell cycle progression is abolished by tuberin’s protective binding to p27.
Protein_catabolism (degradation) of p27
2) Confidence 0.09 Published 2008 Journal Current Genomics Section Body Doc Link PMC2691673 Disease Relevance 0.35 Pain Relevance 0
The observed binding of the tumour suppressor protein tuberin to the tumour suppressor protein p27 provides a molecular explanation for the effects of the TSC genes on p27 protein stability [97].
Protein_catabolism (stability) of p27 associated with cancer
3) Confidence 0.06 Published 2008 Journal Current Genomics Section Body Doc Link PMC2691673 Disease Relevance 0.49 Pain Relevance 0
Skp2 is the F-box protein, which together with other proteins forms an SCF-type E3 ubiquitin ligase complex, whose task is to target p27 for degradation by the proteasome [95, 96].
Protein_catabolism (degradation) of p27
4) Confidence 0.06 Published 2008 Journal Current Genomics Section Body Doc Link PMC2691673 Disease Relevance 0.12 Pain Relevance 0

General Comments

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