INT271939

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Context Info
Confidence 0.41
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.16
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Tsc1) embryo development (Tsc1) protein complex (Tsc1)
cytoplasm (Tsc1)
Anatomy Link Frequency
neuronal 1
Tsc1 (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate 117 98.72 Very High Very High Very High
Central nervous system 7 61.92 Quite High
Neurotransmitter 6 50.00 Quite Low
adenocard 1 41.36 Quite Low
anesthesia 1 40.80 Quite Low
Hippocampus 24 5.00 Very Low Very Low Very Low
chemokine 9 5.00 Very Low Very Low Very Low
nMDA receptor 6 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 9 98.12 Very High Very High Very High
Embryonic Lethality 2 97.56 Very High Very High Very High
Lifespan 6 95.36 Very High Very High Very High
Death 14 93.80 High High
Hamartoma 8 92.56 High High
Tuberous Sclerosis 12 81.32 Quite High
Targeted Disruption 81 80.24 Quite High
Toxicity 3 56.48 Quite High
Pressure And Volume Under Development 1 43.28 Quite Low
Disease 34 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Knocking out either a single transporter gene, or the Tsc1 gene which affects the expression and function of Glu transporters, leads to dramatic reductions in the life span of the mutant mice (lifespan of 3-4 months) [16-18].
Regulation (affects) of Tsc1 associated with glutamate and lifespan
1) Confidence 0.41 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2896956 Disease Relevance 0.69 Pain Relevance 0.47
Down-regulation of hamartin with TSC1 siRNA led to failure of NGF-induced apoptosis in PC12h cells suggesting that the association of hamartin with NADE is involved in neuronal cell death, which could explain why hamartoma cells are not eliminated in TSC.
Regulation (regulation) of hamartin in neuronal associated with hamartoma, apoptosis and death
2) Confidence 0.35 Published 2008 Journal Current Genomics Section Body Doc Link PMC2691673 Disease Relevance 0.47 Pain Relevance 0

General Comments

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