INT271943

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Context Info
Confidence 0.52
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 14
Disease Relevance 3.35
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Tsc2) signal transduction (Tsc2) Golgi apparatus (Tsc2)
nucleus (Tsc2) protein complex (Tsc2) cytoplasm (Tsc2)
Tsc2 (Mus musculus)
Pain Link Frequency Relevance Heat
adenocard 5 83.52 Quite High
ischemia 2 69.28 Quite High
Kinase C 2 50.84 Quite High
agonist 46 5.00 Very Low Very Low Very Low
Clonidine 6 5.00 Very Low Very Low Very Low
Substantia nigra 6 5.00 Very Low Very Low Very Low
antagonist 6 5.00 Very Low Very Low Very Low
carbamazepine 6 5.00 Very Low Very Low Very Low
Inflammation 6 5.00 Very Low Very Low Very Low
cerebral cortex 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Tuberous Sclerosis 63 100.00 Very High Very High Very High
Starvation 38 99.86 Very High Very High Very High
Hypertrophy 15 96.28 Very High Very High Very High
Cancer 131 93.68 High High
Hamartoma 40 89.44 High High
Death 48 88.04 High High
Apoptosis 47 83.88 Quite High
Dna Damage 6 80.56 Quite High
Disease 197 78.64 Quite High
Targeted Disruption 65 70.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
1 antagonises PKB phosphorylation of TSC2 [40], [55].
Phosphorylation (phosphorylation) of TSC2
1) Confidence 0.52 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905373 Disease Relevance 0.36 Pain Relevance 0
Under the condition of starvation, AMPK phosphorylates tuberous sclerosis 2 (TSC2), which inhibits mTOR/S6K1 pathway [39]: phosphorylation of TSC2 by AMPK is critical in the process of mRNA translation and cell size regulation during energy deficiency (Figure 2).
Phosphorylation (phosphorylates) of TSC2 associated with starvation and tuberous sclerosis
2) Confidence 0.47 Published 2010 Journal PPAR Research Section Body Doc Link PMC2929615 Disease Relevance 0.33 Pain Relevance 0.06
Under the condition of starvation, AMPK phosphorylates tuberous sclerosis 2 (TSC2), which inhibits mTOR/S6K1 pathway [39]: phosphorylation of TSC2 by AMPK is critical in the process of mRNA translation and cell size regulation during energy deficiency (Figure 2).
Phosphorylation (phosphorylation) of TSC2 associated with starvation and tuberous sclerosis
3) Confidence 0.47 Published 2010 Journal PPAR Research Section Body Doc Link PMC2929615 Disease Relevance 0.34 Pain Relevance 0.03
The R611Q, R611W, A614D, C696Y and V769E substitutions [51] disrupted the tuberin–hamartin interaction, and prevented the phosphorylation of tuberin by PKB, the inhibition of S6 and S6K phosphorylation, and the stimulation of Rheb GTPase activity, cause TSC because they result in major conformational changes to tuberin.
Phosphorylation (phosphorylation) of tuberin
4) Confidence 0.41 Published 2008 Journal Current Genomics Section Body Doc Link PMC2691673 Disease Relevance 0.06 Pain Relevance 0
The phosphorylation of tuberin by Akt and MK2 promotes the binding of tuberin with 14-3-3 proteins. 14-3-3 proteins are members of a group of proteins that specifically interact with phosphorylated proteins, facilitating the phosphorylation-dependent control of protein activity [83].
Phosphorylation (phosphorylation) of tuberin
5) Confidence 0.41 Published 2008 Journal Current Genomics Section Body Doc Link PMC2691673 Disease Relevance 0 Pain Relevance 0.04
Akt-mediated phosphorylation of tuberin has been demonstrated to regulate both, the translocation of tuberin from the membrane to cytosol and the nuclear/cytoplasmic localisation of tuberin [44].


Phosphorylation (phosphorylation) of tuberin
6) Confidence 0.41 Published 2008 Journal Current Genomics Section Body Doc Link PMC2691673 Disease Relevance 0.27 Pain Relevance 0
Direct evidence has shown that G i/o - and G q -coupled receptors can regulate tuberin phosphorylation in a PI3K-dependent or –independent manner, while G 12/13 may have a dual role in regulating tuberin.
Phosphorylation (phosphorylation) of tuberin
7) Confidence 0.41 Published 2008 Journal Current Genomics Section Body Doc Link PMC2691673 Disease Relevance 0.41 Pain Relevance 0
AMPK, activated when cells are energy-depleted as it senses changes in intracellular AMP/ATP ratios, directly phosphorylates TSC2, thereby providing the priming phosphorylation for subsequent phosphorylation of TSC2 by glycogen synthase kinase 3 (GSK3) to inhibit mTOR signalling [19].
Phosphorylation (phosphorylation) of TSC2
8) Confidence 0.31 Published 2010 Journal Seminars in Cell & Developmental Biology Section Body Doc Link PMC2938570 Disease Relevance 0.39 Pain Relevance 0
Phosphorylation of TSC2 by these kinases leads to the disruption of the heterodimer with TSC1, resulting in loss of TSC1/TSC2 activity.
Phosphorylation (Phosphorylation) of TSC2
9) Confidence 0.31 Published 2010 Journal Seminars in Cell & Developmental Biology Section Body Doc Link PMC2938570 Disease Relevance 0.16 Pain Relevance 0
AMPK, activated when cells are energy-depleted as it senses changes in intracellular AMP/ATP ratios, directly phosphorylates TSC2, thereby providing the priming phosphorylation for subsequent phosphorylation of TSC2 by glycogen synthase kinase 3 (GSK3) to inhibit mTOR signalling [19].
Phosphorylation (phosphorylates) of TSC2
10) Confidence 0.31 Published 2010 Journal Seminars in Cell & Developmental Biology Section Body Doc Link PMC2938570 Disease Relevance 0.32 Pain Relevance 0
The phosphorylation-dependent Akt activation results in the phosphorylation of a host of other proteins, including the tuberous sclerosis complex 1/2 (TSC1/TSC2).
Phosphorylation (phosphorylation) of TSC2 associated with tuberous sclerosis
11) Confidence 0.30 Published 2010 Journal Seminars in Cell & Developmental Biology Section Body Doc Link PMC2938570 Disease Relevance 0.17 Pain Relevance 0
The phosphorylation-dependent Akt activation results in the phosphorylation of a host of other proteins, including the tuberous sclerosis complex 1/2 (TSC1/TSC2).
Phosphorylation (phosphorylation) of TSC2 associated with tuberous sclerosis
12) Confidence 0.30 Published 2010 Journal Seminars in Cell & Developmental Biology Section Body Doc Link PMC2938570 Disease Relevance 0.17 Pain Relevance 0
The K599M substitution is a de novo mutation [46] and has been shown to reduce the tuberin–dependent inhibition of phosphorylation of overexpressed 4E-BP1 [52].
Phosphorylation (phosphorylation) of tuberin
13) Confidence 0.28 Published 2008 Journal Current Genomics Section Body Doc Link PMC2691673 Disease Relevance 0 Pain Relevance 0
AMPK, activated when cells are energy-depleted as it senses changes in intracellular AMP/ATP ratios, directly phosphorylates TSC2, thereby providing the priming phosphorylation for subsequent phosphorylation of TSC2 by glycogen synthase kinase 3 (GSK3) to inhibit mTOR signalling [19].
Phosphorylation (phosphorylation) of TSC2
14) Confidence 0.23 Published 2010 Journal Seminars in Cell & Developmental Biology Section Body Doc Link PMC2938570 Disease Relevance 0.39 Pain Relevance 0

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