INT271944

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Context Info
Confidence 0.30
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.42
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Tsc2) signal transduction (Tsc2) Golgi apparatus (Tsc2)
nucleus (Tsc2) protein complex (Tsc2) cytoplasm (Tsc2)
Tsc2 (Mus musculus)
Pain Link Frequency Relevance Heat
cerebral cortex 1 5.00 Very Low Very Low Very Low
transdermal 1 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
Angina 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
isoflurane 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypertrophy 15 96.92 Very High Very High Very High
Targeted Disruption 17 70.80 Quite High
Congenital Anomalies 3 60.48 Quite High
Tuberous Sclerosis 11 50.00 Quite Low
Obesity 2 37.40 Quite Low
Disease 21 32.72 Quite Low
Sprains And Strains 7 28.20 Quite Low
Cancer 21 5.00 Very Low Very Low Very Low
Angiomyolipoma 12 5.00 Very Low Very Low Very Low
Lymphangioleiomyomatosis 11 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The R611Q, R611W, A614D, C696Y and V769E substitutions [51] disrupted the tuberin–hamartin interaction, and prevented the phosphorylation of tuberin by PKB, the inhibition of S6 and S6K phosphorylation, and the stimulation of Rheb GTPase activity, cause TSC because they result in major conformational changes to tuberin.
Negative_regulation (prevented) of Phosphorylation (phosphorylation) of tuberin
1) Confidence 0.30 Published 2008 Journal Current Genomics Section Body Doc Link PMC2691673 Disease Relevance 0.06 Pain Relevance 0
1 antagonises PKB phosphorylation of TSC2 [40], [55].
Negative_regulation (antagonises) of Phosphorylation (phosphorylation) of TSC2
2) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905373 Disease Relevance 0.36 Pain Relevance 0

General Comments

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