INT271963

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Context Info
Confidence 0.31
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.02
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TSC1) embryo development (TSC1) protein complex (TSC1)
cytoplasm (TSC1)
TSC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
palliative 1 5.00 Very Low Very Low Very Low
cerebral cortex 1 5.00 Very Low Very Low Very Low
transdermal 1 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
Angina 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 76 100.00 Very High Very High Very High
Skin Cancer 62 97.56 Very High Very High Very High
Monosomy 20 94.56 High High
Melanoma 91 91.44 High High
Chromosome Aberrations 10 85.80 High High
Apoptosis 7 78.00 Quite High
Aneuploidy 2 60.16 Quite High
Congenital Anomalies 7 57.36 Quite High
Tuberous Sclerosis 11 50.00 Quite Low
Disease 25 29.60 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The R611Q, R611W, A614D, C696Y and V769E substitutions [51] disrupted the tuberin–hamartin interaction, and prevented the phosphorylation of tuberin by PKB, the inhibition of S6 and S6K phosphorylation, and the stimulation of Rheb GTPase activity, cause TSC because they result in major conformational changes to tuberin.
Phosphorylation (phosphorylation) of TSC
1) Confidence 0.31 Published 2008 Journal Current Genomics Section Body Doc Link PMC2691673 Disease Relevance 0.06 Pain Relevance 0
Phosphatase and tensin homolog (PTEN) is one of the identified tumor suppressor genes, located on 10q23, with strong evidence for a role in CM tumorigenesis [92] (Table 2).
Phosphorylation (Phosphatase) of tumor suppressor associated with cancer and skin cancer
2) Confidence 0.09 Published 2010 Journal Dermatology Research and Practice Section Body Doc Link PMC2902045 Disease Relevance 1.97 Pain Relevance 0

General Comments

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