INT271979

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Context Info
Confidence 0.01
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.35
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Psmd9) kinase activity (Skp2)
Skp2 (Mus musculus)
Psmd9 (Mus musculus)
Pain Link Frequency Relevance Heat
cerebral cortex 1 5.00 Very Low Very Low Very Low
transdermal 1 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
Angina 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 20 91.28 High High
Stress 2 57.52 Quite High
Tuberous Sclerosis 11 50.00 Quite Low
Apoptosis 3 41.12 Quite Low
Hamartoma 8 25.36 Quite Low
Death 4 23.96 Low Low
Disease 21 5.00 Very Low Very Low Very Low
Angiomyolipoma 12 5.00 Very Low Very Low Very Low
Lymphangioleiomyomatosis 11 5.00 Very Low Very Low Very Low
Convulsion 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, binding of tuberin to p27 sequesters p27 from Skp2 accompanied by a stabilization of the p27 interaction with cdk2, and hence, Skp2-induced p27 degradation and cell cycle progression is abolished by tuberin’s protective binding to p27.
Skp2 Positive_regulation (induced) of Protein_catabolism (degradation) of p27
1) Confidence 0.01 Published 2008 Journal Current Genomics Section Body Doc Link PMC2691673 Disease Relevance 0.35 Pain Relevance 0

General Comments

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