INT272010

Context Info Confidence 0.17 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.60 Pain Relevance 0

cytoplasm (Tsc2, OGG1) nucleus (Tsc2, OGG1) nucleoplasm (OGG1) mitochondrion (OGG1) lyase activity (OGG1) Golgi apparatus (Tsc2)

Tsc2 (Mus musculus) OGG1 (Homo sapiens)

Pain Link Frequency Relevance Heat cerebral cortex 1 5.00 transdermal 1 5.00 adenocard 1 5.00 Angina 1 5.00

Disease Link Frequency Relevance Heat Apoptosis 3 99.96 Stress 2 94.40 Cancer 20 90.00 Tuberous Sclerosis 11 73.12 Sprains And Strains 3 47.84 Renal Cancer 3 37.52 Disease 21 28.72 Angiomyolipoma 12 5.00 Lymphangioleiomyomatosis 11 5.00 Convulsion 9 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Tuberin downregulates the DNA repair enzyme 8-oxoguanine DNA-glycosylase (OGG1) with important functional consequences, compromising the ability of cells to repair damaged DNA resulting in the accumulation of the mutagenic oxidized DNA, 8-oxo-dG.

Tuberin Negative_regulation (downregulates) of OGG1

1) Confidence 0.17 Published 2008 Journal Current Genomics Section Body Doc Link PMC2691673 Disease Relevance 0.60 Pain Relevance 0

General Comments

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