INT272144

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Context Info
Confidence 0.08
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.08
Pain Relevance 0.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (PTAFR) plasma membrane (PTAFR) nucleus (PTAFR)
cytoplasm (HRASLS) signal transducer activity (PTAFR)
Anatomy Link Frequency
cornea 1
PTAFR (Homo sapiens)
HRASLS (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 72 99.40 Very High Very High Very High
agonist 15 92.88 High High
antagonist 57 88.76 High High
Inflammatory response 3 84.00 Quite High
bradykinin 3 79.40 Quite High
Inflammation 15 67.52 Quite High
Pain 6 62.24 Quite High
Potency 75 5.00 Very Low Very Low Very Low
metalloproteinase 3 5.00 Very Low Very Low Very Low
Serotonin 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pruritus 6 99.12 Very High Very High Very High
Conjunctivitis 6 99.08 Very High Very High Very High
Edema 15 98.60 Very High Very High Very High
Adhesions 3 88.80 High High
INFLAMMATION 18 83.60 Quite High
Apoptosis 3 81.44 Quite High
Hypersensitivity 24 73.48 Quite High
Conjunctiva Disease 3 64.24 Quite High
Pain 6 62.24 Quite High
Ocular Hypertension 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, the activation of the phospholipase A2/cyclooxygenase pathway by PAF in the HCECs cannot be ruled out at this stage and requires further study.
PAF Positive_regulation (activation) of phospholipase
1) Confidence 0.08 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2693427 Disease Relevance 0.16 Pain Relevance 0.21
In summary, PAF potently activates the phospholipase C-coupled signal cascade system to initiate the synthesis and secretion of numerous proinflammatory cytokines in HCECs.
PAF Positive_regulation (activates) of phospholipase associated with cytokine
2) Confidence 0.08 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2693427 Disease Relevance 0.74 Pain Relevance 0.48
While the predominant effect of PAF in the rabbit cornea appears to be to activate the phospholipase A2/cyclooxygenase pathway [5] and to release leukotrienes that cause conjunctivitis [23], the work presented here has shown that PAF activates the phospholipase C-mediated events in HCECs to release cytokines.
PAF Positive_regulation (activates) of phospholipase in cornea associated with conjunctivitis and cytokine
3) Confidence 0.05 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2693427 Disease Relevance 0.17 Pain Relevance 0.20

General Comments

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