INT272161

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Context Info
Confidence 0.24
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.20
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Gh1, Gh1, Bcl2) nucleus (Gh1, Gh1, Bcl2) cytosol (Gh1, Gh1, Bcl2)
extracellular space (Gh1, Gh1) plasma membrane (Gh1, Gh1) signal transduction (Gh1, Gh1)
Anatomy Link Frequency
neuronal 2
Gh1 (Rattus norvegicus)
Gh1 (Rattus norvegicus)
Bcl2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Thalamus 2 90.60 High High
Hippocampus 1 90.04 High High
cerebral cortex 1 89.52 High High
Intracerebroventricular 26 88.96 High High
Inflammatory response 1 18.36 Low Low
Central nervous system 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
halothane 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 10 97.98 Very High Very High Very High
Injury 22 97.52 Very High Very High Very High
Hypoxia 27 97.20 Very High Very High Very High
Apoptosis 21 51.08 Quite High
Brain Hemorrhage 5 50.00 Quite Low
Necrosis 5 35.64 Quite Low
INFLAMMATION 1 18.00 Low Low
Pressure And Volume Under Development 1 15.96 Low Low
Asphyxia 2 6.80 Low Low
Brain Injury 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although the mechanism is not completely known, several reports suggest that hypoxic-ischemic injury induces neuronal death by downregulating Bcl-2 protein levels, followed by sequential activation of the caspases, and that GH protects neuronal cells by inhibiting alterations in Bcl-2 protein levels and caspase activities (12, 13).
GH Negative_regulation (inhibiting) of GH Regulation (alterations) of Bcl-2 in neuronal associated with hypoxia, injury and death
1) Confidence 0.24 Published 2007 Journal Journal of Korean Medical Science Section Body Doc Link PMC2693548 Disease Relevance 1.20 Pain Relevance 0.26

General Comments

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