INT272202

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Context Info
Confidence 0.59
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 0.99
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (CAPN3) protein complex assembly (CAPN3) protein complex (CAPN3)
cytoplasm (CAPN3) signal transducer activity (CAPN3) cytosol (CAPN3)
Anatomy Link Frequency
bands 1
CAPN3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 9 75.36 Quite High
ischemia 6 5.00 Very Low Very Low Very Low
addiction 3 5.00 Very Low Very Low Very Low
tolerance 3 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Autolysis 18 99.74 Very High Very High Very High
Muscular Dystrophy 57 81.04 Quite High
Pain 9 75.36 Quite High
Congenital Anomalies 3 56.00 Quite High
Hypertrophy 3 54.24 Quite High
Muscular Atrophy 9 53.64 Quite High
Targeted Disruption 3 27.32 Quite Low
Disease 12 5.00 Very Low Very Low Very Low
Contracture 6 5.00 Very Low Very Low Very Low
Brain Hemorrhage 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Western blotting for dysferlin was then performed on the patients with defective signal on at least one kind of calpain 3 antibody, to exclude secondary calpain 3 deficiency due to dysferlin deficiency (11).


Negative_regulation (deficiency) of calpain 3
1) Confidence 0.59 Published 2007 Journal Journal of Korean Medical Science Section Body Doc Link PMC2693639 Disease Relevance 0.11 Pain Relevance 0
Western blot analysis showed that the decrease in identified proteins was rather small compared with the autolytic decrease in p94 (Fig. 5A).
Negative_regulation (decrease) of p94
2) Confidence 0.58 Published 2007 Journal Biotechnology Journal Section Body Doc Link PMC2978325 Disease Relevance 0.23 Pain Relevance 0.14
While autolysis causes down-regulation of p94 as a whole molecule, proteolysis of vimentin would confer other properties on certain parts of the molecule.
Negative_regulation (regulation) of p94 associated with autolysis
3) Confidence 0.43 Published 2007 Journal Biotechnology Journal Section Body Doc Link PMC2978325 Disease Relevance 0.16 Pain Relevance 0.06
No patient with deficient calpain 3 was associated with dysferlin deficiency, supporting the evidence that all of them are primarily deficient for calpain 3.
Negative_regulation (deficient) of calpain 3
4) Confidence 0.38 Published 2007 Journal Journal of Korean Medical Science Section Body Doc Link PMC2693639 Disease Relevance 0.24 Pain Relevance 0
None of the others were deficient for either calpain 3 or dysferlin.


Negative_regulation (deficient) of calpain 3
5) Confidence 0.38 Published 2007 Journal Journal of Korean Medical Science Section Body Doc Link PMC2693639 Disease Relevance 0.24 Pain Relevance 0
An au-tolytic decrease in the full-length p94 in COS7 cells was detected by Western blot analysis, which showed that the amount of WT (addition of 94 kDa, 55 kDa and other smaller bands) is less than 1/100 of that of CS (Fig. 5A “p94”).
Negative_regulation (decrease) of p94 in bands
6) Confidence 0.37 Published 2007 Journal Biotechnology Journal Section Body Doc Link PMC2978325 Disease Relevance 0 Pain Relevance 0

General Comments

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