INT27222

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Context Info
Confidence 0.52
First Reported 1989
Last Reported 2006
Negated 1
Speculated 2
Reported most in Body
Documents 4
Total Number 45
Disease Relevance 24.57
Pain Relevance 2.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (ALPPL2)
Anatomy Link Frequency
blood 3
testis 1
germ cell 1
posterior 1
cervix 1
ALPPL2 (Homo sapiens)
Pain Link Frequency Relevance Heat
lidocaine 3 100.00 Very High Very High Very High
imagery 126 99.12 Very High Very High Very High
Paracetamol 13 97.76 Very High Very High Very High
Pain 1 79.60 Quite High
abdominal pain 42 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nicotine Addiction 546 99.98 Very High Very High Very High
Carcinoma 42 99.98 Very High Very High Very High
Cancer 967 99.78 Very High Very High Very High
Seminoma 256 99.56 Very High Very High Very High
Embryonal Carcinoma 294 98.00 Very High Very High Very High
Recurrence 42 97.36 Very High Very High Very High
Reprotox - General 1 42 96.92 Very High Very High Very High
Ovarian Cancer 210 96.64 Very High Very High Very High
Testicular Cancer 84 92.60 High High
Germ Cell And Embryonal Neoplasms 42 90.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunocytochemistry revealed these anaplastic cells to be cytokeratin and placenta-like alkaline phosphatase positive but S100, CD30 and lymphoid marker negative.
Neg (negative) Gene_expression (positive) of placenta-like alkaline phosphatase in placenta
1) Confidence 0.52 Published 2000 Journal Ann. Oncol. Section Abstract Doc Link 10942066 Disease Relevance 0.71 Pain Relevance 0.08
express predominantly the PLAP-like enzyme, while embryonal
Gene_expression (express) of PLAP-like enzyme
2) Confidence 0.52 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1559920 Disease Relevance 1.12 Pain Relevance 0
levels of PLAP/PLAP-like were observed in 2 patients with
Gene_expression (levels) of PLAP-like
3) Confidence 0.52 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1559920 Disease Relevance 1.13 Pain Relevance 0.09
hPLAP/PLAP-like activity above 0.2 U/L (cutoff value in
Gene_expression (activity) of PLAP-like
4) Confidence 0.45 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1559920 Disease Relevance 1.18 Pain Relevance 0.07
Since PLAP/PLAP-like activity could be detected at very low levels
Gene_expression (activity) of PLAP-like
5) Confidence 0.45 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1559920 Disease Relevance 0.74 Pain Relevance 0
Our data show that the normal serum value for PLAP/PLAP-like enzyme activity in adult nonsmokers is around
Gene_expression (activity) of PLAP-like enzyme
6) Confidence 0.45 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1559920 Disease Relevance 0.12 Pain Relevance 0
Average hPLAP/PLAP-like activity for nonsmoker blood donors was
Gene_expression (activity) of PLAP-like in blood
7) Confidence 0.45 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1559920 Disease Relevance 0.14 Pain Relevance 0
PLAP/PLAP-like enzyme activity
Gene_expression (activity) of PLAP-like enzyme
8) Confidence 0.45 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1559920 Disease Relevance 0.45 Pain Relevance 0
samples, ICA-PLAP would reveal other PLAP/PLAP-like phenotypes in
Gene_expression (phenotypes) of PLAP-like
9) Confidence 0.45 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1559920 Disease Relevance 0 Pain Relevance 0
A normal Gaussian distribution of hPLAP/PLAP-like
Gene_expression (/) of PLAP-like
10) Confidence 0.45 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1559920 Disease Relevance 0.19 Pain Relevance 0
one PLAP-Ab that is capable of recognizing most PLAP/PLAP-like
Gene_expression (most) of PLAP-like
11) Confidence 0.45 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1559920 Disease Relevance 0.06 Pain Relevance 0.03
Following the first cycle of chemotherapy, PLAP/PLAP-like serum
Gene_expression (serum) of PLAP-like
12) Confidence 0.45 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1559920 Disease Relevance 0.86 Pain Relevance 0.04
The PLAP-like enzyme is encoded
Gene_expression (encoded) of PLAP-like enzyme
13) Confidence 0.45 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1559920 Disease Relevance 0.06 Pain Relevance 0
Due to their high homology, PLAP and PLAP-like enzymes cannot be
Gene_expression (enzymes) of PLAP-like
14) Confidence 0.45 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1559920 Disease Relevance 1.12 Pain Relevance 0
than testing for CA 125 (71%–85%) and alpha-fetoprotein

(AFP) (88%) [44]; however, testing for PLAP/PLAP-like

Gene_expression (/) of PLAP-like
15) Confidence 0.45 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1559920 Disease Relevance 0.88 Pain Relevance 0
developed assays could also be used to detect PLAP/PLAP-like
Gene_expression (detect) of PLAP-like
16) Confidence 0.45 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1559920 Disease Relevance 0.84 Pain Relevance 0.03
A normal Gaussian distribution of hPLAP/PLAP-like
Gene_expression (distribution) of PLAP-like
17) Confidence 0.45 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1559920 Disease Relevance 0.19 Pain Relevance 0
peptide aa 57–71 of hPLAP differs in 2 residues from PLAP-like, 3
Gene_expression (differs) of PLAP-like
18) Confidence 0.45 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1559920 Disease Relevance 0 Pain Relevance 0
release PLAP-like enzymes into the blood [21, 39], possibly in
Gene_expression (enzymes) of PLAP-like in blood
19) Confidence 0.45 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1559920 Disease Relevance 0.44 Pain Relevance 0
0.20 U/L (I), respectively, for ICA-PLAP, and 0.23 U/L

(NI) and 0.22 U/L (I) for ICA-PEP. hPLAP/PLAP-like enzyme

Gene_expression (/) of PLAP-like enzyme
20) Confidence 0.45 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1559920 Disease Relevance 0.23 Pain Relevance 0.04

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