INT272253

Context Info Confidence 0.37 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0.18

plasma membrane (Dlg4) protein complex assembly (Dlg4) response to stress (Dlg4) cytoplasm (Dlg4)

Anatomy Link Frequency neurons 2 Dlg4 (Rattus norvegicus)

Pain Link Frequency Relevance Heat addiction 5 100.00 tetrodotoxin 16 66.64 imagery 20 5.00 Action potential 5 5.00 Central nervous system 3 5.00 Glutamate receptor 2 5.00 antagonist 2 5.00 Neurotransmitter 1 5.00 nMDA receptor 1 5.00 Glutamate 1 5.00

Disease Link Frequency Relevance Heat Pathologic Processes 2 5.00 Increased Venous Pressure Under Development 1 5.00 Nervous System Malformation 1 5.00 Stress 1 5.00 Infection 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Despite the reduction in activity levels, changes in puncta fluorescence still occurred to similar degrees, although the dependence of such changes on initial PSD-95:GFP puncta fluorescence was reduced or lost, in particular at higher diazepam concentrations (five experiments, tracked synapse data from four neurons).

Negative_regulation (reduced) of Regulation (dependence) of PSD-95 in neurons associated with addiction

1) Confidence 0.37 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2693930 Disease Relevance 0 Pain Relevance 0.18

General Comments

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