INT272264

Context Info Confidence 0.22 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.09 Pain Relevance 0

plasma membrane (Dlg4, Psd) cytoplasm (Dlg4, Psd) intracellular (Psd) protein complex assembly (Dlg4) response to stress (Dlg4)

Anatomy Link Frequency synapse 1 Dlg4 (Rattus norvegicus) Psd (Rattus norvegicus)

Pain Link Frequency Relevance Heat imagery 20 40.56 tetrodotoxin 16 23.36 Glutamate 1 18.64 addiction 5 5.00 Action potential 5 5.00 Central nervous system 3 5.00 Glutamate receptor 2 5.00 antagonist 2 5.00 Neurotransmitter 1 5.00 nMDA receptor 1 5.00

Disease Link Frequency Relevance Heat Pathologic Processes 2 93.76 Increased Venous Pressure Under Development 1 5.00 Nervous System Malformation 1 5.00 Stress 1 5.00 Infection 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In the aforementioned experiments, we observed significant changes in PSD-95:GFP puncta number and fluorescence intensity, which, in all likelihood, reflected changes in glutamatergic synapse number and PSD size.

PSD-95 Regulation (changes) of PSD in synapse

1) Confidence 0.22 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2693930 Disease Relevance 0.09 Pain Relevance 0

General Comments

This test has worked.