INT272272

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Context Info
Confidence 0.40
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 17
Total Number 18
Disease Relevance 18.85
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
Eyes 4
plasma 2
external 2
NARFL (Homo sapiens)
Pain Link Frequency Relevance Heat
fibrosis 9 73.20 Quite High
anesthesia 25 56.60 Quite High
Pain 33 53.04 Quite High
cva 22 23.20 Low Low
dexamethasone 1 14.64 Low Low
metalloproteinase 44 5.00 Very Low Very Low Very Low
Inflammation 43 5.00 Very Low Very Low Very Low
beta blocker 30 5.00 Very Low Very Low Very Low
agonist 27 5.00 Very Low Very Low Very Low
antagonist 15 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ocular Hypertension 1925 100.00 Very High Very High Very High
Glaucoma 458 99.80 Very High Very High Very High
Hypertension 13 99.04 Very High Very High Very High
Ocular Toxicity (including Many Sub-types) 64 94.44 High High
Low Tension Glaucoma 27 94.12 High High
Syndrome 3 91.36 High High
Pressure And Volume Under Development 26 89.64 High High
Open-angle Glaucoma 26 88.40 High High
Foreign Bodies 4 86.68 High High
Renal Disease 6 83.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moderate and important IOP elevations above the preoperative baseline were defined as ?
Positive_regulation (important) of Gene_expression (elevations) of IOP associated with ocular hypertension
1) Confidence 0.40 Published 2008 Journal Clinical ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2698684 Disease Relevance 0.84 Pain Relevance 0.06
Eyes that receive IVTA need to be monitored for IOP changes especially during the first 3 months.
Positive_regulation (monitored) of Gene_expression (changes) of IOP in Eyes associated with ocular hypertension
2) Confidence 0.31 Published 2008 Journal Clinical ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2693970 Disease Relevance 1.03 Pain Relevance 0
Most of the oxybuprocaine subjects presented with an IOP change within Ā±2 mmHg (of the initial IOP) after instillation of the eyedrops, with approximately 87% (two minutes and five minutes post eyedrop instillation) showing an IOP change that ranged from +1 mmHg to ?
Positive_regulation (ranged) of Gene_expression (change) of IOP associated with ocular hypertension
3) Confidence 0.27 Published 2007 Journal Clinical ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2701119 Disease Relevance 1.16 Pain Relevance 0
The results from the current study can not be explained by a transient increase in corneal thickness as such an increase should lead to an overestimation of IOP not an underestimation.
Positive_regulation (overestimation) of Gene_expression (overestimation) of IOP associated with ocular hypertension
4) Confidence 0.27 Published 2007 Journal Clinical ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2701119 Disease Relevance 0.77 Pain Relevance 0
This relation between plasma osmolarity and IOP during hemodialysis has been studied since the report of Sitprija and coworkers.9-11 They first discovered that a rapid decrease in plasma osmolarity caused markedly increased IOP levels during hemodialysis.
Positive_regulation (increased) of Gene_expression (levels) of IOP in plasma associated with ocular hypertension
5) Confidence 0.21 Published 2006 Journal Korean Journal of Ophthalmology : KJO Section Body Doc Link PMC2908824 Disease Relevance 1.53 Pain Relevance 0.05
Masuda et al.7 reported that Argon laser trabeculoplasty successfully controlled the IOP elevation in exfoliative glaucoma patients showing intradialytic IOP elevation, while Choong et al.6 reported that bilateral IOP elevation after hemodialysis stabilized with topical ?
Positive_regulation (intradialytic) of Gene_expression (elevation) of IOP associated with glaucoma and ocular hypertension
6) Confidence 0.21 Published 2006 Journal Korean Journal of Ophthalmology : KJO Section Body Doc Link PMC2908824 Disease Relevance 1.50 Pain Relevance 0.10
Masuda et al.7 reported that Argon laser trabeculoplasty successfully controlled the IOP elevation in exfoliative glaucoma patients showing intradialytic IOP elevation, while Choong et al.6 reported that bilateral IOP elevation after hemodialysis stabilized with topical ?
Positive_regulation (showing) of Gene_expression (elevation) of IOP associated with glaucoma and ocular hypertension
7) Confidence 0.21 Published 2006 Journal Korean Journal of Ophthalmology : KJO Section Body Doc Link PMC2908824 Disease Relevance 1.50 Pain Relevance 0.10
Likewise, Orzalesi et al found that both FCDT and latanoprost resulted in similar circadian reductions in IOP without statistically significant differences between the mean diurnal IOP values between the two groups (Orzalesi et al 2003).
Positive_regulation (reductions) of Gene_expression (values) of IOP associated with ocular hypertension
8) Confidence 0.18 Published 2008 Journal Clinical ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2693974 Disease Relevance 0.80 Pain Relevance 0
Mean average IOP reductions from baseline were ?
Positive_regulation (average) of Gene_expression (average) of IOP associated with ocular hypertension
9) Confidence 0.11 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2993108 Disease Relevance 0.81 Pain Relevance 0
7.8 mmHg mean IOP reduction) for the brimonidineĀ–timolol therapy and 15.4 mmHg (?
Positive_regulation (mean) of Gene_expression (reduction) of IOP associated with ocular hypertension
10) Confidence 0.11 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2993108 Disease Relevance 1.14 Pain Relevance 0
Another meta-analysis105 found travoprost 0.004% was equivalent in lowering IOP compared with bimatoprost 0.03%85,86,92,93,95 (WMD = 0.08, P = 0.8) or latanoprost 0.005%68,85,93,95,98,104 (WMD = ?
Positive_regulation (equivalent) of Gene_expression (lowering) of IOP associated with ocular hypertension
11) Confidence 0.04 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2915861 Disease Relevance 0.41 Pain Relevance 0
The largest of the studies analyzed75 documented a significant lowering of diurnal IOP with latanoprost (8.5 mmHg) than dorzolamide (5.6 mmHg; P < 0.001).75

Rank order of ocular hypotensives as monotherapy

Positive_regulation (lowering) of Gene_expression (significant) of IOP associated with ocular hypertension
12) Confidence 0.04 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2915861 Disease Relevance 0.57 Pain Relevance 0
Another meta-analysis105 found travoprost 0.004% was equivalent in lowering IOP compared with bimatoprost 0.03%85,86,92,93,95 (WMD = 0.08, P = 0.8) or latanoprost 0.005%68,85,93,95,98,104 (WMD = ?
Positive_regulation (lowering) of Gene_expression (lowering) of IOP associated with ocular hypertension
13) Confidence 0.04 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2915861 Disease Relevance 0.41 Pain Relevance 0
In timolol-treated subjects, adjunctive latanoprost lowered IOP significantly more than adjunctive dorzolamide (?
Positive_regulation (lowered) of Gene_expression (lowered) of IOP associated with ocular hypertension
14) Confidence 0.04 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2915861 Disease Relevance 0.81 Pain Relevance 0
During the course of the study they were removed en bloc in most cases for fast IOP control; however, in two cases where stents were serially removed, additional stent removal resulted in additional IOP reduction, suggesting the advantage of multiple thin external stents.
Positive_regulation (resulted) of Gene_expression (reduction) of IOP in external associated with ocular hypertension
15) Confidence 0.03 Published 2009 Journal Korean Journal of Ophthalmology : KJO Section Body Doc Link PMC2694298 Disease Relevance 0.65 Pain Relevance 0
All eyes had an IOP of ?
Positive_regulation (eyes) of Gene_expression (had) of IOP in eyes associated with ocular hypertension
16) Confidence 0.03 Published 2009 Journal Korean Journal of Ophthalmology : KJO Section Body Doc Link PMC2694298 Disease Relevance 1.49 Pain Relevance 0
The hypertensive phase (HP) was defined as that period when the IOP rose to >21 mmHg during the first 3 postoperative months following an IOP reduction to ?
Positive_regulation (following) of Gene_expression (reduction) of IOP associated with hypertension and ocular hypertension
17) Confidence 0.03 Published 2009 Journal Korean Journal of Ophthalmology : KJO Section Body Doc Link PMC2694298 Disease Relevance 1.70 Pain Relevance 0
The hypertensive phase (HP) was defined as that period when the IOP rose to >21 mmHg during the first 3 postoperative months following an IOP reduction to ?
Positive_regulation (following) of Gene_expression (rose) of IOP associated with hypertension and ocular hypertension
18) Confidence 0.03 Published 2009 Journal Korean Journal of Ophthalmology : KJO Section Body Doc Link PMC2694298 Disease Relevance 1.73 Pain Relevance 0

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