INT272275

Context Info Confidence 0.36 First Reported 2006 Last Reported 2010 Negated 1 Speculated 2 Reported most in Body Documents 8 Total Number 12 Disease Relevance 16.68 Pain Relevance 0.86

Anatomy Link Frequency eyes 6 medial 2 NARFL (Homo sapiens)

Pain Link Frequency Relevance Heat Pain 32 100.00 Inflammation 88 98.82 fibrosis 13 98.36 headache 8 74.48 ischemia 50 64.08 eye pain 4 42.00 Calcium channel 9 5.00 Rheumatism 8 5.00 cva 7 5.00 corticosteroid 6 5.00

Disease Link Frequency Relevance Heat Ocular Hypertension 669 100.00 Pain 32 100.00 Disease Progression 7 100.00 Glaucoma 357 99.66 Shock 8 98.92 INFLAMMATION 90 98.82 Blister 13 98.68 Fibrosis 13 98.36 Disease 46 95.28 Uveitis 9 95.12

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The significant increase in IOP levels observed in the first hour in our cases was probably due to the volume-effect of the injected IVTA; only 8.8% of the eyes showed a moderately elevated IOP in the first hour postinjection.

Regulation (effect) of Positive_regulation (increase) of IOP in eyes associated with ocular hypertension

1) Confidence 0.36 Published 2008 Journal Clinical ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2698684 Disease Relevance 1.36 Pain Relevance 0

This was because intradialytic IOP elevations were controlled before the formation of the fibrous membrane.

Regulation (controlled) of Positive_regulation (elevations) of IOP associated with ocular hypertension

2) Confidence 0.26 Published 2006 Journal Korean Journal of Ophthalmology : KJO Section Body Doc Link PMC2908824 Disease Relevance 1.76 Pain Relevance 0.14

Masuda et al.7 reported that Argon laser trabeculoplasty successfully controlled the IOP elevation in exfoliative glaucoma patients showing intradialytic IOP elevation, while Choong et al.6 reported that bilateral IOP elevation after hemodialysis stabilized with topical ?

Regulation (controlled) of Positive_regulation (elevation) of IOP associated with glaucoma and ocular hypertension

3) Confidence 0.26 Published 2006 Journal Korean Journal of Ophthalmology : KJO Section Body Doc Link PMC2908824 Disease Relevance 1.42 Pain Relevance 0.07

In this subgroup, anti-glaucoma therapy was given to control IOP increase at month 1 after the first IVTA injection in 3 eyes (IOP range: 28–42 mmHg), at month 3 after the first IVTA injection in 7 eyes (IOP range: 28–38 mmHg), and at month 6 after a second IVTA injection in 5 eyes (IOP range: 25–40 mmHg).

Regulation (control) of Positive_regulation (increase) of IOP in eyes associated with glaucoma and ocular hypertension

4) Confidence 0.17 Published 2008 Journal Clinical ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2693970 Disease Relevance 1.61 Pain Relevance 0

There have been studies on Korean nonglaucomatous patients with IOP elevations during hemodialysis and also on the medial control of intradialytic IOP elevation in Korean nonglaucomatous patients; but reports on glaucoma patients have been limited.

Regulation (control) of Positive_regulation (elevation) of IOP in medial associated with glaucoma and ocular hypertension

5) Confidence 0.12 Published 2006 Journal Korean Journal of Ophthalmology : KJO Section Body Doc Link PMC2908824 Disease Relevance 1.50 Pain Relevance 0.07

Further treatments with intravenous mannitol, oral carbonic anhydrase inhibitor, topical antiglaumatic agents and subconjunctival 5-fluorouracil (5-FU) injections all failed to control relapsing pain and IOP elevation.

Neg (failed) Regulation (control) of Positive_regulation (elevation) of IOP associated with pain and ocular hypertension

6) Confidence 0.12 Published 2006 Journal Korean Journal of Ophthalmology : KJO Section Abstract Doc Link PMC2908824 Disease Relevance 1.21 Pain Relevance 0.18

Molecular characteristic of OVDs should have significant effects on the likelihood of IOP elevation.

Regulation (effects) of Positive_regulation (elevation) of IOP associated with ocular hypertension

7) Confidence 0.09 Published 2008 Journal Clinical ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2698691 Disease Relevance 1.14 Pain Relevance 0

Other glaucoma risk factors that may be responsible for disease progression despite lowering of IOP include vascular risk factors, genetics, and other systemic conditions (Leske 2007).

Spec (may) Regulation (responsible) of Positive_regulation (lowering) of IOP associated with glaucoma, ocular hypertension and disease progression

8) Confidence 0.06 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699797 Disease Relevance 2.20 Pain Relevance 0

Our study showed that both the APACG group and the CPACG group had significantly higher IOP levels and corresponding significantly higher flare value and cell counts than the healthy control group, implying that IOP elevation might be responsible for the changes of the BAB in the two PACG groups.

Spec (might) Regulation (responsible) of Positive_regulation (elevation) of IOP associated with glaucoma and ocular hypertension

9) Confidence 0.06 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2965576 Disease Relevance 1.48 Pain Relevance 0.14

The effect of IOP elevation on the BAB was accessed by comparing flare value and cell counts of the two PACG groups to those of the age-matched healthy control group.

Regulation (effect) of Positive_regulation (elevation) of IOP associated with glaucoma and ocular hypertension

10) Confidence 0.05 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2965576 Disease Relevance 1.16 Pain Relevance 0.06

In this study, we used laser flare cell photometry for aqueous flare and cells measurements to both quantitatively evaluate the inflammation in the anterior chamber in eyes with PACG and explore the influence of IOP elevation on the BAB.

Regulation (influence) of Positive_regulation (elevation) of IOP in eyes associated with inflammation, glaucoma and ocular hypertension

11) Confidence 0.03 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2965576 Disease Relevance 0.89 Pain Relevance 0.08

However, the effect of IOP elevation as a potential mechanical shock on the BAB has not been studied until the present.

Regulation (effect) of Positive_regulation (elevation) of IOP associated with shock and ocular hypertension

12) Confidence 0.03 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2965576 Disease Relevance 0.94 Pain Relevance 0.12

General Comments

This test has worked.