INT27228

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Context Info
Confidence 0.23
First Reported 1987
Last Reported 2000
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 11
Disease Relevance 0.91
Pain Relevance 2.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Pigm)
Anatomy Link Frequency
thymocytes 2
hippocampus 2
Pigm (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 2 99.22 Very High Very High Very High
Hippocampus 27 98.74 Very High Very High Very High
conotoxin 1 97.58 Very High Very High Very High
aspirin 6 97.36 Very High Very High Very High
dexamethasone 1 96.64 Very High Very High Very High
Opioid 1 94.96 High High
Enkephalin 16 92.24 High High
medulla 1 87.04 High High
Spinal cord 6 85.92 High High
Neuropeptide 6 84.56 Quite High
Disease Link Frequency Relevance Heat
Convulsion 11 98.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pretreatment of cells with cycloheximide (a protein synthesis inhibitor; 10 microM) did not affect the forskolin- or PMA-induced increase in proDYN mRNA, but pretreatment with nimodipine (a L-type Ca2+ channel blocker; 2 microM), omega-conotoxin (a N-type Ca2+ channel blocker; 1 microM), or KN-62 (a Ca2+/calmodulin-dependent protein kinase II inhibitor; 5 microM) inhibited induction of proDYN mRNA both by forskolin and PMA.
Negative_regulation (inhibited) of Positive_regulation (induction) of proDYN mRNA associated with conotoxin
1) Confidence 0.23 Published 1997 Journal Neuropeptides Section Abstract Doc Link 9179864 Disease Relevance 0 Pain Relevance 0.41
A combination of peripheral acting cholinergic antagonists (chlorisondamine plus methylatropine) prevented the MTZ-induction of adrenal c-fos and PPenk mRNA without significant alterations in the MTZ-induction of hippocampal c-fos mRNA or convulsions.
Negative_regulation (prevented) of Positive_regulation (induction) of PPenk mRNA associated with convulsion and antagonist
2) Confidence 0.05 Published 1993 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8255173 Disease Relevance 0.19 Pain Relevance 0.33
The elevations of both proENK and proDYN mRNA levels induced by KA were inhibited by pre-administration with phenidone, but not with esculetin and aspirin.
Negative_regulation (inhibited) of Positive_regulation (induced) of proDYN mRNA associated with aspirin
3) Confidence 0.04 Published 1998 Journal Brain Res. Section Abstract Doc Link 9519284 Disease Relevance 0.26 Pain Relevance 0.36
This was not the case when these cells were incubated with Con A during the same period of time; whereas, in thymocytes the presence of PEA mRNA was exclusively dependent upon mitogenic stimulus (Con A) and could be detected after 24 h of in vitro incubation.
Negative_regulation (detected) of Positive_regulation (presence) of mRNA in thymocytes
4) Confidence 0.04 Published 1989 Journal J. Immunol. Section Abstract Doc Link 2584715 Disease Relevance 0 Pain Relevance 0.26
The elevations of both proENK and proDYN mRNA levels induced by KA were significantly inhibited by the preadministration with melatonin.
Negative_regulation (inhibited) of Positive_regulation (elevations) of proDYN mRNA
5) Confidence 0.04 Published 2000 Journal Hippocampus Section Abstract Doc Link 10902893 Disease Relevance 0 Pain Relevance 0.08
The elevations of both proENK and proDYN mRNA levels induced by KA were significantly inhibited by the preadministration with melatonin.
Negative_regulation (inhibited) of Positive_regulation (induced) of proDYN mRNA
6) Confidence 0.03 Published 2000 Journal Hippocampus Section Abstract Doc Link 10902893 Disease Relevance 0 Pain Relevance 0.08
The elevations of both proENK and proDYN mRNA levels induced by KA was effectively inhibited by pre-administration of L-ARG (400 mg/kg, i.p.), but was not affected by pre-treatment with L-NAME (200 mg/kg, i.p.).
Negative_regulation (inhibited) of Positive_regulation (induced) of proDYN mRNA
7) Confidence 0.03 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9602069 Disease Relevance 0 Pain Relevance 0.08
In the adrenal, both the basal levels and the MTZ induction of PPenk mRNA were significantly attenuated by hypophysectomy (hypox) and were partially reinstated by adrenocorticotropic hormone (ACTH) replacement.
Negative_regulation (reinstated) of Positive_regulation (induction) of PPenk mRNA
8) Confidence 0.02 Published 1993 Journal Mol. Pharmacol. Section Abstract Doc Link 8102782 Disease Relevance 0.07 Pain Relevance 0.25
The elevations of both proENK and proDYN mRNA levels induced by KA were inhibited by pre-administration of CHX (15 mg/kg i.p.).
Negative_regulation (inhibited) of Positive_regulation (elevations) of proDYN mRNA
9) Confidence 0.02 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9221929 Disease Relevance 0 Pain Relevance 0.08
The elevations of both proENK and proDYN mRNA levels induced by KA was effectively inhibited by pre-administration of L-ARG (400 mg/kg, i.p.), but was not affected by pre-treatment with L-NAME (200 mg/kg, i.p.).
Negative_regulation (inhibited) of Positive_regulation (elevations) of proDYN mRNA
10) Confidence 0.02 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9602069 Disease Relevance 0 Pain Relevance 0.09
In hippocampus a large and very rapid increase in c-fos mRNA was observed to precede the previously reported increase in preproenkephalin mRNA following hilus lesion-induced seizures.
Negative_regulation (precede) of Positive_regulation (increase) of mRNA in hippocampus associated with convulsion and hippocampus
11) Confidence 0.01 Published 1987 Journal Brain Res. Section Abstract Doc Link 3427445 Disease Relevance 0.39 Pain Relevance 0.48

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