INT27229

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Context Info
Confidence 0.27
First Reported 1989
Last Reported 2000
Negated 1
Speculated 0
Reported most in Abstract
Documents 13
Total Number 14
Disease Relevance 0.78
Pain Relevance 2.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Pigm)
Anatomy Link Frequency
macrophage 2
thymocytes 2
hippocampus 2
Pigm (Rattus norvegicus)
Pain Link Frequency Relevance Heat
aspirin 15 99.76 Very High Very High Very High
Hippocampus 29 99.48 Very High Very High Very High
Calcium channel 2 98.44 Very High Very High Very High
Kinase C 6 94.12 High High
Spinal cord 11 92.52 High High
antagonist 2 88.32 High High
Enkephalin 19 87.92 High High
dexamethasone 2 87.24 High High
nMDA receptor 1 84.72 Quite High
Neuropeptide 2 80.24 Quite High
Disease Link Frequency Relevance Heat
Convulsion 9 96.00 Very High Very High Very High
Disease 1 65.72 Quite High
Injury 2 50.00 Quite Low
Cancer 1 5.00 Very Low Very Low Very Low
Necrosis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The proDYN mRNA level began to increase 1 h, then reached and remained at a peak 3-6 h after stimulation by forskolin or PMA. proDYN mRNA levels in forskolin treated cells decreased slightly from their peak after 9 h of treatment, whereas the level of proDYN mRNA returned to the basal level in PMA-treated cells.
Positive_regulation (returned) of Positive_regulation (level) of proDYN mRNA
1) Confidence 0.27 Published 1997 Journal Neuropeptides Section Abstract Doc Link 9179864 Disease Relevance 0 Pain Relevance 0.33
Calcium influx through both L- and N-type calcium channels and Ca2+/calmodulin-dependent protein kinase II appear to be involved in the increase of proDYN mRNA levels induced by either forskolin or PMA.
Positive_regulation (increase) of Positive_regulation (induced) of proDYN mRNA associated with calcium channel
2) Confidence 0.27 Published 1997 Journal Neuropeptides Section Abstract Doc Link 9179864 Disease Relevance 0 Pain Relevance 0.26
Trifluoperazine, a calcium/calmodulin inhibitor, attenuated the MTZ-induction of c-fos mRNA while potentiating the MTZ-induction of PPenk mRNA in both the hippocampus and the adrenal.
Positive_regulation (potentiating) of Positive_regulation (induction) of PPenk mRNA in hippocampus associated with hippocampus
3) Confidence 0.08 Published 1993 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8255173 Disease Relevance 0.17 Pain Relevance 0.32
This was not the case when these cells were incubated with Con A during the same period of time; whereas, in thymocytes the presence of PEA mRNA was exclusively dependent upon mitogenic stimulus (Con A) and could be detected after 24 h of in vitro incubation.
Positive_regulation (dependent) of Positive_regulation (presence) of mRNA in thymocytes
4) Confidence 0.04 Published 1989 Journal J. Immunol. Section Abstract Doc Link 2584715 Disease Relevance 0 Pain Relevance 0.24
The elevations of both proENK and proDYN mRNA levels induced by KA were inhibited by pre-administration with phenidone, but not with esculetin and aspirin.
Positive_regulation (elevations) of Positive_regulation (induced) of proDYN mRNA associated with aspirin
5) Confidence 0.03 Published 1998 Journal Brain Res. Section Abstract Doc Link 9519284 Disease Relevance 0.26 Pain Relevance 0.36
The increases of proENK and proDYN mRNA levels induced by KA were well correlated with the increases of Fra protein level.
Positive_regulation (induced) of Positive_regulation (increases) of proDYN mRNA
6) Confidence 0.03 Published 1998 Journal Brain Res. Section Abstract Doc Link 9519284 Disease Relevance 0.23 Pain Relevance 0.39
The elevations of both proENK and proDYN mRNA levels induced by KA were significantly inhibited by the preadministration with melatonin.
Positive_regulation (induced) of Positive_regulation (elevations) of proDYN mRNA
7) Confidence 0.03 Published 2000 Journal Hippocampus Section Abstract Doc Link 10902893 Disease Relevance 0 Pain Relevance 0.08
The elevations of both proENK and proDYN mRNA levels induced by KA were significantly inhibited by the preadministration with melatonin.
Positive_regulation (elevations) of Positive_regulation (induced) of proDYN mRNA
8) Confidence 0.03 Published 2000 Journal Hippocampus Section Abstract Doc Link 10902893 Disease Relevance 0 Pain Relevance 0.08
Thus, in hypox rats MTZ can increase adrenal c-fos and TH mRNA levels without a corresponding increase in PPenk mRNA, whereas in ACTH-treated rats PPenk and TH mRNA levels in adrenal can be increased by MTZ without a preceding increase in c-fos mRNA.
Positive_regulation (increase) of Neg (without) Positive_regulation (increase) of PPenk mRNA
9) Confidence 0.02 Published 1993 Journal Mol. Pharmacol. Section Abstract Doc Link 8102782 Disease Relevance 0.05 Pain Relevance 0.17
The increases of proENK and proDYN mRNA levels induced by KA were well-correlated with the increases of c-Fos, 35-kDa Fra and c-Jun protein levels.
Positive_regulation (increases) of Positive_regulation (induced) of proDYN mRNA
10) Confidence 0.02 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9221929 Disease Relevance 0 Pain Relevance 0.08
The increases of proENK and proDYN mRNA levels induced by KA were well-correlated with the increases of c-Fos, 35-kDa Fra and c-Jun protein levels.
Positive_regulation (induced) of Positive_regulation (increases) of proDYN mRNA
11) Confidence 0.02 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9221929 Disease Relevance 0 Pain Relevance 0.08
The elevations of both proENK and proDYN mRNA levels induced by KA was effectively inhibited by pre-administration of L-ARG (400 mg/kg, i.p.), but was not affected by pre-treatment with L-NAME (200 mg/kg, i.p.).
Positive_regulation (elevations) of Positive_regulation (induced) of proDYN mRNA
12) Confidence 0.02 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9602069 Disease Relevance 0 Pain Relevance 0.09
The elevations of both proENK and proDYN mRNA levels induced by KA was effectively inhibited by pre-administration of L-ARG (400 mg/kg, i.p.), but was not affected by pre-treatment with L-NAME (200 mg/kg, i.p.).
Positive_regulation (induced) of Positive_regulation (elevations) of proDYN mRNA
13) Confidence 0.02 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9602069 Disease Relevance 0 Pain Relevance 0.09
RESULTS: Aspirin increases intracellular calcium (Ca2+) levels and causes a time and concentration dependent increase in macrophage TNFalpha mRNA accumulation and cytokine release.
Positive_regulation (increase) of Positive_regulation (accumulation) of mRNA in macrophage
14) Confidence 0.00 Published 1998 Journal Aliment. Pharmacol. Ther. Section Body Doc Link 9845404 Disease Relevance 0.07 Pain Relevance 0

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