INT2723

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Context Info
Confidence 0.64
First Reported 1976
Last Reported 2008
Negated 0
Speculated 3
Reported most in Abstract
Documents 16
Total Number 19
Disease Relevance 11.78
Pain Relevance 3.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
hepatic artery 1
Liver 1
skeleton 1
bone marrow 1
central nervous system 1
Salpa1 (Mus musculus)
Pain Link Frequency Relevance Heat
depression 6 100.00 Very High Very High Very High
Central nervous system 5 100.00 Very High Very High Very High
abdominal pain 10 99.76 Very High Very High Very High
Pain 15 99.66 Very High Very High Very High
alcohol 8 98.78 Very High Very High Very High
Chronic pancreatitis 2 93.84 High High
Crohn's disease 10 92.48 High High
palliative 3 91.80 High High
Lasting pain 4 91.28 High High
Bile 3 85.20 High High
Disease Link Frequency Relevance Heat
Fever 8 100.00 Very High Very High Very High
Depression 6 100.00 Very High Very High Very High
Extrahepatic Cholestasis 3 99.92 Very High Very High Very High
Inflammatory Bowel Disease 11 99.90 Very High Very High Very High
Metastasis 14 99.88 Very High Very High Very High
Abdominal Pain 10 99.76 Very High Very High Very High
Pain 14 99.66 Very High Very High Very High
Adenocarcinoma 2 99.64 Very High Very High Very High
Postcholecystectomy Syndrome 1 99.08 Very High Very High Very High
Gallbladder Disease 1 99.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Liver abscess should be suspected in patients with regional enteritis who present with fever, elevated serum alkaline phosphatase, liver tenderness, right upper quadrant pain or hepatomegaly.
Gene_expression (present) of serum alkaline phosphatase in Liver associated with pain, inflammatory bowel disease, liver abscess, hepatomegaly and fever
1) Confidence 0.64 Published 1979 Journal Am. J. Gastroenterol. Section Abstract Doc Link 507033 Disease Relevance 0.84 Pain Relevance 0.10
Although abnormal scans were observed with the greatest frequency in patients with bone pain (11 of 11), bone marrow involvement (11 of 12), abnormal skeletal radiographs (11 of 11), and elevated serum alkaline phosphatase levels (5 of 6), bone scanning also detected lymphomatous involvement in patients free of pain or with normal laboratory tests.
Gene_expression (levels) of serum alkaline phosphatase in bone marrow associated with pain
2) Confidence 0.64 Published 1976 Journal Cancer Section Abstract Doc Link 953962 Disease Relevance 0.92 Pain Relevance 0.19
Four patients with acquired immunodeficiency syndrome (AIDS) (CDC group IV) were investigated for biliary disease because of the presence of both severe upper abdominal pain and raised levels of serum alkaline phosphatase.
Gene_expression (levels) of serum alkaline phosphatase in upper associated with abdominal pain, syndrome, acquired immune deficiency syndrome or hiv infection, disease and immunodeficiency
3) Confidence 0.57 Published 1988 Journal Scand. J. Gastroenterol. Section Abstract Doc Link 3074460 Disease Relevance 1.43 Pain Relevance 0.20
A mild transient rise in the levels of serum alkaline phosphatase occurred immediately following radioisotope administration.
Gene_expression (levels) of serum alkaline phosphatase
4) Confidence 0.57 Published 1990 Journal J. Nucl. Med. Section Abstract Doc Link 2341893 Disease Relevance 0.52 Pain Relevance 0.31
They showed markedly raised levels of serum alkaline phosphatase, whereas serum phosphorus, serum calcium levels and antistreptolycin O-titres were normal in 93% cases.
Gene_expression (levels) of serum alkaline phosphatase
5) Confidence 0.44 Published 1989 Journal Indian J. Physiol. Pharmacol. Section Abstract Doc Link 2620972 Disease Relevance 0.31 Pain Relevance 0.23
U.) which relieved bone pain and lowered the levels of serum alkaline phosphatase to normal within 14 weeks of initiation of therapy.
Gene_expression (levels) of serum alkaline phosphatase associated with pain
6) Confidence 0.44 Published 1989 Journal Indian J. Physiol. Pharmacol. Section Abstract Doc Link 2620972 Disease Relevance 0.41 Pain Relevance 0.33
Inhalation exposures of rats, mice, and rabbits to 3000 ppm Methoxyisopropanol for 6 h per day for 9 days to 13 weeks produced increased relative liver weights, signs of central nervous system (CNS) depression, and in some cases, elevated serum alkaline phosphatase, alanine aminotransferase, or hepatocellular hypertrophy, but the kidneys were unaffected.
Gene_expression (produced) of serum alkaline phosphatase in central nervous system associated with hypertrophy, depression and central nervous system
7) Confidence 0.37 Published 2008 Journal Int. J. Toxicol. Section Abstract Doc Link 18830862 Disease Relevance 0.57 Pain Relevance 0.15
It may rarely be the cause of an elevated serum alkaline phosphatase and/or amylase when abdominal pain is not present.
Gene_expression (cause) of serum alkaline phosphatase associated with abdominal pain
8) Confidence 0.25 Published 1984 Journal Hepatology Section Abstract Doc Link 6200420 Disease Relevance 0.55 Pain Relevance 0.45
Serum alkaline phosphatase, bilirubin and ESR were raised in most cases.
Gene_expression (raised) of Serum alkaline phosphatase
9) Confidence 0.24 Published 1983 Journal Ann. Acad. Med. Singap. Section Abstract Doc Link 6678137 Disease Relevance 0.95 Pain Relevance 0.09
Parenteral drug abusers (n = 34) were significantly younger than alcohol abusers (n = 23) or abusers of both (n = 147) and had lower levels of serum alkaline phosphatase, total bilirubin, and aspartate aminotransferase than the other two groups.
Gene_expression (levels) of serum alkaline phosphatase associated with alcohol
10) Confidence 0.24 Published 1986 Journal Alcohol. Clin. Exp. Res. Section Abstract Doc Link 3541673 Disease Relevance 0.62 Pain Relevance 0.33
Serum alkaline phosphatase, bilirubin and alanine aminotransferase were measured in rats 3 h after sham operation (group A, N = 29) or ligation of the hepatic artery (group B, N = 29).
Gene_expression (measured) of Serum alkaline phosphatase in hepatic artery
11) Confidence 0.12 Published 1990 Journal Braz. J. Med. Biol. Res. Section Abstract Doc Link 2101073 Disease Relevance 0.43 Pain Relevance 0.13
Mononuclear leucocyte zinc was determined together with serum zinc, albumin and serum alkaline phosphatase activity before and after zinc supplementation (2 x 50 mg of zinc-gluconate daily during 3 months) in patients with alcoholic liver cirrhosis (n = 10), alcoholic chronic pancreatitis (n = 10) and Crohn's disease (n = 10).
Spec (determined) Gene_expression (activity) of serum alkaline phosphatase in leucocyte associated with crohn's disease, disease, alcoholic liver cirrhosis and chronic pancreatitis
12) Confidence 0.10 Published 1989 Journal J Trace Elem Electrolytes Health Dis Section Abstract Doc Link 2535348 Disease Relevance 0.64 Pain Relevance 0.29
Bone metastases were determined by focal skeleton pains, elevated serum alkaline phosphatase levels, adenocarcinoma, KPS</=70, sensitivity of 90.6, specificity of 12.7, PPV of 16.3, NPV of 87.8, and silent metastases rate (SMR) of 9.4%.
Spec (determined) Gene_expression (determined) of serum alkaline phosphatase in skeleton associated with adenocarcinoma and metastasis
13) Confidence 0.08 Published 2007 Journal Lung Cancer Section Abstract Doc Link 17566597 Disease Relevance 1.45 Pain Relevance 0.07
There was an increase in serum glutamic pyruvic transaminase (SGPT) and serum alkaline phosphatase (SAP) level with the crude extract but stagninol showed no significant changes of serum glutamic oxaloacetic transaminase (SGOT), SGPT and SAP level.
Gene_expression (level) of serum alkaline phosphatase
14) Confidence 0.07 Published 1997 Journal Pharmazie Section Abstract Doc Link 9260269 Disease Relevance 0.24 Pain Relevance 0.15
Serum alkaline phosphatase rose during the first 8 weeks of treatment in the timegadine group.
Gene_expression (rose) of Serum alkaline phosphatase
15) Confidence 0.06 Published 1988 Journal Scand. J. Rheumatol. Section Abstract Doc Link 3291099 Disease Relevance 0.42 Pain Relevance 0.21
Serum alkaline phosphatase (SAP) was analyzed in 193 patients treated with total hip arthroplasty (THA) and correlated with the degree of heterotopic bone formation (HBF) one year after surgery.
Spec (analyzed) Gene_expression (analyzed) of Serum alkaline phosphatase in hip
16) Confidence 0.05 Published 1988 Journal Clin. Orthop. Relat. Res. Section Abstract Doc Link 3136963 Disease Relevance 0.06 Pain Relevance 0.07
Serum alkaline phosphatase, uric acid, albumin, bilirubin, mean corpuscular hemoglobin (MCH), mean corpuscular volume (MCV) and monocytes were significantly lower in the cynomogus monkeys.
Gene_expression (lower) of Serum alkaline phosphatase in monocytes
17) Confidence 0.05 Published 1985 Journal Lab. Anim. Sci. Section Abstract Doc Link 3981960 Disease Relevance 0 Pain Relevance 0
Laboratory studies disclosed increases in the serum alkaline phosphatase, glutamic oxaloacetic transaminase, glutamic pyruvic transaminase, and serum amylase levels.
Gene_expression (levels) of serum alkaline phosphatase
18) Confidence 0.04 Published 1998 Journal Hepatogastroenterology Section Abstract Doc Link 9840091 Disease Relevance 0.34 Pain Relevance 0.18
The serum alkaline phosphatase was 1002 IU/L, AST 57 IU/L, ALT 76 IU/L, total bilirubin 6.6 mg/dl, albumin 1.6, total protein 3.6 g/dl and INR 1.5.
Gene_expression (was) of serum alkaline phosphatase
19) Confidence 0.03 Published 2001 Journal BMC Gastroenterol Section Body Doc Link PMC56591 Disease Relevance 1.07 Pain Relevance 0.03

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