INT27230

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Context Info
Confidence 0.75
First Reported 1989
Last Reported 2010
Negated 0
Speculated 6
Reported most in Body
Documents 10
Total Number 16
Disease Relevance 8.57
Pain Relevance 2.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (LTBR)
Anatomy Link Frequency
blood 2
HeLa 2
synovium 2
lymph nodes 1
eosinophils 1
LTBR (Homo sapiens)
Pain Link Frequency Relevance Heat
depression 1 100.00 Very High Very High Very High
Etanercept 113 98.96 Very High Very High Very High
Inflammation 144 97.40 Very High Very High Very High
rheumatoid arthritis 61 95.84 Very High Very High Very High
cytokine 58 94.20 High High
Pain 13 89.28 High High
dexamethasone 1 83.44 Quite High
methotrexate 49 80.80 Quite High
Crohn's disease 1 80.56 Quite High
chemokine 20 75.68 Quite High
Disease Link Frequency Relevance Heat
Cancer 19 100.00 Very High Very High Very High
Necrosis 15 100.00 Very High Very High Very High
Depression 5 100.00 Very High Very High Very High
Rheumatoid Arthritis 97 99.84 Very High Very High Very High
Adhesions 34 98.52 Very High Very High Very High
Disease 128 97.88 Very High Very High Very High
Stress 10 97.68 Very High Very High Very High
Apoptosis 37 97.46 Very High Very High Very High
INFLAMMATION 171 97.40 Very High Very High Very High
Pancreatitis 3 94.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TNF-alpha and interleukin-8 might increase the expression of the CD11b-CD18 constitutively present on the polymorphonuclear neutrophils membrane and facilitate their rolling and diapedesis through the vascular endothelial wall [2,6].
Gene_expression (expression) of CD18 in polymorphonuclear neutrophils
1) Confidence 0.75 Published 2003 Journal BMC Musculoskelet Disord Section Body Doc Link PMC194711 Disease Relevance 1.51 Pain Relevance 0.30
A significant relationship was also found between the extent of the RIII depression during the CP and that during a 10-min period of post-CP observation. 3.
Gene_expression (depression) of RIII associated with depression
2) Confidence 0.67 Published 1989 Journal J. Neurophysiol. Section Abstract Doc Link 2585037 Disease Relevance 0.74 Pain Relevance 0.37
CONCLUSION: rh TNFR:Fc rapidly improves the signs and symptoms of active AS.


Gene_expression (improves) of TNFR
3) Confidence 0.59 Published 2008 Journal Zhonghua Yi Xue Za Zhi Section Body Doc Link 18953881 Disease Relevance 0 Pain Relevance 0
In humans, these cells constitutively express intracellular cytotoxic T-lymphocyte antigen 4 (CTLA-4) and glucocorticoid-induced tumor-necrosis-factor-receptor-related protein (GITR).
Gene_expression (express) of tumor-necrosis-factor-receptor-related protein in cytotoxic T-lymphocyte associated with necrosis and cancer
4) Confidence 0.18 Published 2008 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2633304 Disease Relevance 0.28 Pain Relevance 0.10
Treatment with high dose methylprednisolone results in significant reduction in peripheral blood eosinophils and phenotypic changes characterized by decreased expression of CD11b, CD18, and CD13 which have an important role in the action of eosinophils [46].
Gene_expression (expression) of CD18 in eosinophils
5) Confidence 0.11 Published 2004 Journal Clin Mol Allergy Section Body Doc Link PMC425596 Disease Relevance 0.38 Pain Relevance 0.12
and its designated receptor TNFR.
Gene_expression (designated) of receptor TNFR
6) Confidence 0.10 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2567339 Disease Relevance 0.25 Pain Relevance 0.12
METHODS: To investigate the immune response in the clinical features of chronic pancreatitis, we investigated the gene expression of tumor necrosis factor-alpha (TNF-alpha), tumor necrosis factor receptor (TNFR)-p55 and -p75 and inducible nitric oxide synthase (iNOS) in peripheral blood mononuclear cells (PBMC) of 18 patients with late-stage alcoholic chronic pancreatitis of different disease activity (Balthazar criteria).
Spec (investigated) Gene_expression (expression) of tumor necrosis factor receptor in mononuclear cells
7) Confidence 0.03 Published 1999 Journal Int. J. Pancreatol. Section Body Doc Link 10732290 Disease Relevance 0.27 Pain Relevance 0
Conversely, ectopic overexpression of several related TNFR superfamily members in HeLa cells did not lead to their interaction with Trx1, yet CD30 strongly interacted on the same cells under the same conditions.
Gene_expression (overexpression) of TNFR in HeLa
8) Confidence 0.02 Published 2007 Journal EMBO J Section Body Doc Link PMC1914094 Disease Relevance 0.09 Pain Relevance 0
To further exclude that Trx1 reactivity of receptors is determined or limited by surface expression levels, we ectopically overexpressed CD30 or other TNFR superfamily members under control of the same promoter in HeLa cells and analyzed Trx1 cell surface trapping by indirect immunofluorescence.
Spec (analyzed) Gene_expression (overexpressed) of TNFR in HeLa
9) Confidence 0.02 Published 2007 Journal EMBO J Section Body Doc Link PMC1914094 Disease Relevance 0 Pain Relevance 0
It is possible that activated mDC undergo apoptosis immediately upon entering lymph nodes, or alternatively that other newly identified costimulatory molecules from the CD28 and TNFR families not examined here may be differentially expressed in progressively infected lymph nodes [47].
Gene_expression (expressed) of TNFR in lymph nodes associated with apoptosis
10) Confidence 0.02 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC3009592 Disease Relevance 0.87 Pain Relevance 0.03
Etanercept is a dimeric human tumor necrosis factor receptor (TNFR) p75-Fc fusion protein made of 2 extra-cellular domains of the human 75 kD (p75) TNFR linked by the constant Fc portion of human immunoglobulin 1 (IgG1).
Gene_expression (made) of TNFR associated with necrosis, cancer and etanercept
11) Confidence 0.02 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1936291 Disease Relevance 1.03 Pain Relevance 0.65
Also the domains LDLa, Immunoglobulin I-set, CUB and TNFR were found and they can not be found in mammal Adhesion GPCRs [13].
Gene_expression (found) of TNFR associated with adhesions
12) Confidence 0.01 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2246102 Disease Relevance 0.68 Pain Relevance 0
The objective of this study was to investigate LT-Beta and LT-BetaReceptor (LT-BetaR) gene expression in RA patient synovium and blood samples compared with control individuals, and correlate with LT-Alpha and TNF-Alpha gene expression and disease parameters.
Spec (investigate) Gene_expression (expression) of LT-BetaR in blood associated with rheumatoid arthritis and disease
13) Confidence 0.00 Published 2008 Journal Rheumatol. Int. Section Abstract Doc Link 18379788 Disease Relevance 0.56 Pain Relevance 0.17
RT-PCR was used to investigate the gene expression of LT-Beta, LT-BetaR, TNF-Alpha and LT-Alpha in the blood and synovium of RA patients and a control group of individuals.
Spec (investigate) Gene_expression (expression) of LT-BetaR in synovium associated with rheumatoid arthritis
14) Confidence 0.00 Published 2008 Journal Rheumatol. Int. Section Abstract Doc Link 18379788 Disease Relevance 0.67 Pain Relevance 0.16
The objective of this study was to investigate LT-Beta and LT-BetaReceptor (LT-BetaR) gene expression in RA patient synovium and blood samples compared with control individuals, and correlate with LT-Alpha and TNF-Alpha gene expression and disease parameters.
Spec (investigate) Gene_expression (expression) of LT-BetaR in synovium associated with rheumatoid arthritis and disease
15) Confidence 0.00 Published 2008 Journal Rheumatol. Int. Section Abstract Doc Link 18379788 Disease Relevance 0.56 Pain Relevance 0.17
RT-PCR was used to investigate the gene expression of LT-Beta, LT-BetaR, TNF-Alpha and LT-Alpha in the blood and synovium of RA patients and a control group of individuals.
Spec (investigate) Gene_expression (expression) of LT-BetaR in blood associated with rheumatoid arthritis
16) Confidence 0.00 Published 2008 Journal Rheumatol. Int. Section Abstract Doc Link 18379788 Disease Relevance 0.67 Pain Relevance 0.16

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