INT272342

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Context Info
Confidence 0.58
First Reported 2009
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 5
Total Number 10
Disease Relevance 5.72
Pain Relevance 0.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Adarb1) mRNA processing (Adarb1) nucleolus (Adarb1)
RNA binding (Adarb1) nucleus (Adarb1) intracellular (Adarb1)
Anatomy Link Frequency
neurons 4
brain 2
astrocytes 2
Adarb1 (Mus musculus)
Pain Link Frequency Relevance Heat
ASIC 4 89.68 High High
Central nervous system 42 76.04 Quite High
antagonist 24 74.08 Quite High
Glutamate 71 73.16 Quite High
adenocard 57 68.76 Quite High
Serotonin 42 59.88 Quite High
Glutamate receptor 32 57.76 Quite High
ischemia 39 54.52 Quite High
medulla 5 49.04 Quite Low
tetrodotoxin 7 38.96 Quite Low
Disease Link Frequency Relevance Heat
Thiamine Deficiency 372 100.00 Very High Very High Very High
Targeted Disruption 41 99.44 Very High Very High Very High
Drug Induced Neurotoxicity 24 89.76 High High
Death 93 81.92 Quite High
Neurodegenerative Disease 6 81.80 Quite High
Brain Hemorrhage 6 54.52 Quite High
Motor Neuron Diseases 60 53.76 Quite High
Toxicity 6 41.08 Quite Low
Disease 48 33.80 Quite Low
Neurological Disease 15 33.44 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We examined the effect of TD on the expression of ADAR2 as well as ADAR2 self-editing activity in cultured cortical neurons.
Spec (examined) Regulation (effect) of Gene_expression (expression) of ADAR2 in neurons associated with thiamine deficiency
1) Confidence 0.58 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC3006372 Disease Relevance 0.88 Pain Relevance 0
In the rat brain, both developmental and regional regulation of ADAR2 mRNA expression and splicing are observed [47].
Regulation (regulation) of Gene_expression (expression) of ADAR2 mRNA in brain
2) Confidence 0.48 Published 2009 Journal Mol Brain Section Body Doc Link PMC2694175 Disease Relevance 0.08 Pain Relevance 0.06
Manipulation of ADAR2 expression alters AMPA-mediated Ca2+ influx and TD-induced cytoxicity
Regulation (alters) of Gene_expression (expression) of ADAR2 associated with thiamine deficiency
3) Confidence 0.42 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC3006372 Disease Relevance 0.75 Pain Relevance 0
Over-expression of ADAR2 significantly inhibited an AMPA-mediated rise of [Ca2+]i in cortical neurons; contrarily, down-regulation of ADAR2 enhanced AMPA-mediated Ca2+ influx, indicating the manipulation of ADAR2 expression was sufficient to alter Ca2+ permeability of AMPARs channels (Figure 7).
Regulation (manipulation) of Gene_expression (expression) of ADAR2 in neurons
4) Confidence 0.42 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC3006372 Disease Relevance 1.08 Pain Relevance 0
Interestingly, TD selectively down-regulates ADAR2 expression without affecting ADAR1 in vitro and in vivo, indicating some specificity of TD's action.
Regulation (regulates) of Gene_expression (expression) of ADAR2 associated with thiamine deficiency
5) Confidence 0.37 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC3006372 Disease Relevance 1.14 Pain Relevance 0.07
B regulates the expression of ADAR2 [55]and TD inhibits the transcription activity of NF-?
Regulation (regulates) of Gene_expression (expression) of ADAR2 associated with thiamine deficiency
6) Confidence 0.37 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC3006372 Disease Relevance 1.17 Pain Relevance 0.04
In addition, expression of ADAR1 and ADAR2 does not correspond with editing frequencies of specific target sites in the 5-HT2CR mRNA.
Neg (not) Regulation (correspond) of Gene_expression (expression) of ADAR2
7) Confidence 0.35 Published 2009 Journal Mol Brain Section Body Doc Link PMC2694175 Disease Relevance 0 Pain Relevance 0
Interestingly, the expression of ADAR2 mRNA does not correspond temporally or spatially with its physiological substrates, GluR-B and 5-HT2CR.
Neg (not) Regulation (correspond) of Gene_expression (expression) of ADAR2 mRNA
8) Confidence 0.35 Published 2009 Journal Mol Brain Section Body Doc Link PMC2694175 Disease Relevance 0.07 Pain Relevance 0
Our results show that TD down-regulates the expression of ADAR2 and inhibits GluR2 pre-mRNA editing at the Q/R site, resulting in increased Ca2+ permeability.
Regulation (regulates) of Gene_expression (expression) of ADAR2
9) Confidence 0.25 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC3006372 Disease Relevance 0.44 Pain Relevance 0.09
To record Ca2+ activity in astrocytes, slices were loaded with Fluo-4 and astrocytes were identified by using a transgenic animal in which astrocytes express monomeric red fluorescent protein 1 (mRFP1) under the GFAP promoter (Hirrlinger et al., 2005).
Regulation (under) of Gene_expression (express) of red fluorescent protein 1 in astrocytes associated with targeted disruption
10) Confidence 0.01 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2888059 Disease Relevance 0.10 Pain Relevance 0.25

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