INT272344

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Context Info
Confidence 0.57
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 1.85
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mRNA processing (Adar) nucleolus (Adar) RNA binding (Adar)
nucleus (Adar) intracellular (Adar) DNA binding (Adar)
Anatomy Link Frequency
neurons 1
brain 1
ADAR 1
Adar (Mus musculus)
Pain Link Frequency Relevance Heat
Serotonin 42 71.84 Quite High
ischemia 23 46.80 Quite Low
adenocard 41 38.72 Quite Low
tetrodotoxin 2 26.52 Quite Low
antagonist 6 24.52 Low Low
Glutamate receptor 15 12.44 Low Low
Glutamate 36 5.00 Very Low Very Low Very Low
Central nervous system 18 5.00 Very Low Very Low Very Low
Action potential 15 5.00 Very Low Very Low Very Low
potassium channel 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Thiamine Deficiency 124 99.58 Very High Very High Very High
Targeted Disruption 25 87.12 High High
Cv Unclassified Under Development 21 46.80 Quite Low
Neurodegenerative Disease 6 36.48 Quite Low
Motor Neuron Diseases 48 5.00 Very Low Very Low Very Low
Death 41 5.00 Very Low Very Low Very Low
Stress 28 5.00 Very Low Very Low Very Low
Epilepsy 27 5.00 Very Low Very Low Very Low
Cancer 27 5.00 Very Low Very Low Very Low
Disease 24 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although the editing efficacies markedly increase during development, ADAR1 mRNA expression remains constant, suggesting that other factors may cooperate with ADAR1 such as RNA helicase [49,50].
Transcription (expression) of ADAR1
1) Confidence 0.57 Published 2009 Journal Mol Brain Section Body Doc Link PMC2694175 Disease Relevance 0 Pain Relevance 0
Hence, although the mRNA level of ADAR1 and ADAR2 may play critical physiological roles in the brain and peripheral tissues, changes in the expression of these enzymes alone could not account for the developmental regulation of RNA editing observed in the brain.


Transcription (level) of ADAR1 in brain
2) Confidence 0.57 Published 2009 Journal Mol Brain Section Body Doc Link PMC2694175 Disease Relevance 0 Pain Relevance 0.04
Regulation of ADAR activity by alternative splicing
Transcription (activity) of ADAR in ADAR
3) Confidence 0.54 Published 2009 Journal Mol Brain Section Body Doc Link PMC2694175 Disease Relevance 0.09 Pain Relevance 0
Furthermore, TD in C57BL/6J mice also selectively reduced both mRNA and protein levels of ADAR2, but not that of ADAR1 (Figure 4C, 4D and 4F).
Transcription (levels) of ADAR1 associated with thiamine deficiency
4) Confidence 0.46 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC3006372 Disease Relevance 0.90 Pain Relevance 0
A real-time PCR study showed that TD down-regulated mRNA levels of ADAR2, but not that of ADAR1 in cortical neurons (Figure 4E).
Transcription (levels) of ADAR1 in neurons associated with thiamine deficiency
5) Confidence 0.46 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC3006372 Disease Relevance 0.86 Pain Relevance 0

General Comments

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