INT272351

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Context Info
Confidence 0.50
First Reported 2009
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 1.56
Pain Relevance 0.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mRNA processing (Adar) nucleolus (Adar) RNA binding (Adar)
nucleus (Adar) intracellular (Adar) DNA binding (Adar)
Anatomy Link Frequency
ADAR 2
brain 1
Adar (Mus musculus)
Pain Link Frequency Relevance Heat
Endep 17 97.42 Very High Very High Very High
fluoxetine 33 97.06 Very High Very High Very High
adenocard 44 95.40 Very High Very High Very High
Central nervous system 19 74.64 Quite High
Hippocampus 18 70.72 Quite High
ischemia 23 53.12 Quite High
Serotonin 57 50.00 Quite Low
Spinal cord 2 30.72 Quite Low
Glutamate 36 5.00 Very Low Very Low Very Low
Glutamate receptor 16 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Thiamine Deficiency 124 98.94 Very High Very High Very High
Targeted Disruption 34 94.12 High High
Death 41 78.48 Quite High
Aging 8 63.60 Quite High
Brain Hemorrhage 2 53.12 Quite High
Motor Neuron Diseases 48 52.36 Quite High
Toxicity 2 39.68 Quite Low
Disease 24 32.40 Quite Low
Neurological Disease 7 32.04 Quite Low
Frailty 2 31.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, fluoxetine and amitriptyline increase the editing frequencies at the A and B sites by increasing the simultaneous editing of those two sites, most likely by regulating ADAR1 activity.
Regulation (regulating) of ADAR1 associated with endep and fluoxetine
1) Confidence 0.50 Published 2010 Journal Nucleic Acids Research Section Body Doc Link PMC2879535 Disease Relevance 0 Pain Relevance 0.71
First, ADAR1 and ADAR2 could be regulated at the post-transcriptional level such as protein modification or compartmentalization, which would enhance enzyme activity or its access to substrates.
Regulation (regulated) of ADAR1
2) Confidence 0.49 Published 2009 Journal Mol Brain Section Body Doc Link PMC2694175 Disease Relevance 0 Pain Relevance 0
Regulation of ADAR activity by self-editing
Regulation (Regulation) of ADAR in ADAR
3) Confidence 0.49 Published 2009 Journal Mol Brain Section Body Doc Link PMC2694175 Disease Relevance 0 Pain Relevance 0.10
Interestingly, TD selectively down-regulates ADAR2 expression without affecting ADAR1 in vitro and in vivo, indicating some specificity of TD's action.
Neg (without) Regulation (affecting) of ADAR1 associated with thiamine deficiency
4) Confidence 0.41 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC3006372 Disease Relevance 1.19 Pain Relevance 0.06
Regulation of ADAR activity by alternative splicing
Regulation (Regulation) of ADAR in ADAR
5) Confidence 0.21 Published 2009 Journal Mol Brain Section Body Doc Link PMC2694175 Disease Relevance 0.09 Pain Relevance 0
TD selectively decreased ADAR2 expression and its self-editing ability without affecting ADAR1 in cultured neurons and in the brain tissue.
Neg (without) Regulation (affecting) of ADAR1 in brain
6) Confidence 0.18 Published 2010 Journal Mol Neurodegener Section Abstract Doc Link PMC3006372 Disease Relevance 0.28 Pain Relevance 0.11

General Comments

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