INT272358

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Context Info
Confidence 0.73
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 19
Total Number 48
Disease Relevance 26.94
Pain Relevance 3.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Adarb1) mRNA processing (Adarb1) nucleolus (Adarb1)
RNA binding (Adarb1) nucleus (Adarb1) intracellular (Adarb1)
Anatomy Link Frequency
neurons 16
brain 6
forebrain 3
astrocytes 1
Adarb1 (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 200 99.92 Very High Very High Very High
Hippocampus 53 99.04 Very High Very High Very High
adenocard 299 97.56 Very High Very High Very High
Serotonin 239 96.48 Very High Very High Very High
ASIC 4 89.68 High High
Glutamate receptor 144 87.32 High High
Neuronal excitability 16 87.16 High High
Central nervous system 213 75.64 Quite High
antagonist 97 74.08 Quite High
Glutamate 273 73.16 Quite High
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 170 99.92 Very High Very High Very High
Thiamine Deficiency 1860 99.84 Very High Very High Very High
Targeted Disruption 189 99.44 Very High Very High Very High
Drug Induced Neurotoxicity 120 98.88 Very High Very High Very High
Brain Tumor 32 98.76 Very High Very High Very High
Death 470 98.48 Very High Very High Very High
Neurodegenerative Disease 32 97.64 Very High Very High Very High
Injury 76 95.32 Very High Very High Very High
Glioblastoma 80 95.00 High High
Malignant Neoplastic Disease 32 94.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Over-expression of ADAR2 significantly inhibited an AMPA-mediated rise of [Ca2+]i in cortical neurons; contrarily, down-regulation of ADAR2 enhanced AMPA-mediated Ca2+ influx, indicating the manipulation of ADAR2 expression was sufficient to alter Ca2+ permeability of AMPARs channels (Figure 7).
Gene_expression (expression) of ADAR2 in neurons
1) Confidence 0.73 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC3006372 Disease Relevance 1.07 Pain Relevance 0
To further determine the role of ADAR2 in AMPA-mediated Ca2+ influx and TD-induced cytoxicity, we manipulated the expression of ADAR2 in cortical neurons.
Gene_expression (expression) of ADAR2 in neurons associated with thiamine deficiency
2) Confidence 0.73 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC3006372 Disease Relevance 0.60 Pain Relevance 0
Furthermore, TD in C57BL/6J mice also selectively reduced both mRNA and protein levels of ADAR2, but not that of ADAR1 (Figure 4C, 4D and 4F).
Gene_expression (levels) of ADAR2 associated with thiamine deficiency
3) Confidence 0.73 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC3006372 Disease Relevance 0.89 Pain Relevance 0
We increased ADAR2 expression in cortical neurons by transfecting cells with a wild type ADAR2 cDNA, and decreased its expression by treating it with a short hairpin RNA (shRNA) of ADAR2.
Gene_expression (expression) of ADAR2 in neurons
4) Confidence 0.73 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC3006372 Disease Relevance 0.54 Pain Relevance 0
Manipulation of ADAR2 expression alters AMPA-mediated Ca2+ influx and TD-induced cytoxicity
Gene_expression (expression) of ADAR2 associated with thiamine deficiency
5) Confidence 0.73 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC3006372 Disease Relevance 0.75 Pain Relevance 0
As shown in Figure 6 transfection of ADAR2 cDNA effectively increased ADAR2 expression, whereas shADAR2 decreased ADAR2 expression in cortical neurons.
Gene_expression (expression) of ADAR2 in neurons
6) Confidence 0.73 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC3006372 Disease Relevance 0.78 Pain Relevance 0
As shown in Figure 8 over-expression of ADAR2 significantly ameliorated TD-induced death of cortical neurons; while down-regulation of ADAR2 enhanced TD-induced death of cortical neurons.
Gene_expression (expression) of ADAR2 in neurons associated with thiamine deficiency and death
7) Confidence 0.73 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC3006372 Disease Relevance 1.26 Pain Relevance 0
We examined the effect of TD on the expression of ADAR2 as well as ADAR2 self-editing activity in cultured cortical neurons.
Gene_expression (expression) of ADAR2 in neurons associated with thiamine deficiency
8) Confidence 0.73 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC3006372 Disease Relevance 0.88 Pain Relevance 0
TD decreases ADAR2 expression and activity
Gene_expression (expression) of ADAR2 associated with thiamine deficiency
9) Confidence 0.73 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC3006372 Disease Relevance 0.86 Pain Relevance 0
As shown in Figure 6 transfection of ADAR2 cDNA effectively increased ADAR2 expression, whereas shADAR2 decreased ADAR2 expression in cortical neurons.
Gene_expression (expression) of ADAR2 in neurons
10) Confidence 0.73 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC3006372 Disease Relevance 0.74 Pain Relevance 0
Over-expression of ADAR2 significantly inhibited an AMPA-mediated rise of [Ca2+]i in cortical neurons; contrarily, down-regulation of ADAR2 enhanced AMPA-mediated Ca2+ influx, indicating the manipulation of ADAR2 expression was sufficient to alter Ca2+ permeability of AMPARs channels (Figure 7).
Gene_expression (expression) of ADAR2 in neurons
11) Confidence 0.73 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC3006372 Disease Relevance 0.86 Pain Relevance 0
Immunoblotting analysis indicated that TD significantly decreased the expression of ADAR2, but not ADAR1 in cortical neurons (Figure 4A and 4B).
Gene_expression (expression) of ADAR2 in neurons associated with thiamine deficiency
12) Confidence 0.73 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC3006372 Disease Relevance 0.86 Pain Relevance 0
Interestingly, TD selectively down-regulates ADAR2 expression without affecting ADAR1 in vitro and in vivo, indicating some specificity of TD's action.
Gene_expression (expression) of ADAR2 associated with thiamine deficiency
13) Confidence 0.63 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC3006372 Disease Relevance 1.14 Pain Relevance 0.06
The unedited PCR products of ADAR2 were 102 bp, and the edited PCR products of ADAR2 were 149 bp.
Gene_expression (products) of ADAR2
14) Confidence 0.63 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC3006372 Disease Relevance 0.07 Pain Relevance 0
The decrease in RNA editing at Q/R sites suggests that TD may inhibit ADAR2 activity or expression.
Gene_expression (expression) of ADAR2 associated with thiamine deficiency
15) Confidence 0.63 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC3006372 Disease Relevance 0.88 Pain Relevance 0
The PCR products of ADAR2 were run on a 1% agarose gel and visualized by the Dolphin-Scan image system.
Gene_expression (products) of ADAR2
16) Confidence 0.63 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC3006372 Disease Relevance 0.07 Pain Relevance 0
While transition to edited AMPA correlates with the overexpression of ADAR2, the exact mechanism and/or factors involved in regulation of RNA editing remain to be elucidated.
Gene_expression (overexpression) of ADAR2
17) Confidence 0.61 Published 2009 Journal Mol Brain Section Body Doc Link PMC2694175 Disease Relevance 0.10 Pain Relevance 0.07
Interestingly, the expression of ADAR2 mRNA does not correspond temporally or spatially with its physiological substrates, GluR-B and 5-HT2CR.
Gene_expression (expression) of ADAR2 mRNA
18) Confidence 0.61 Published 2009 Journal Mol Brain Section Body Doc Link PMC2694175 Disease Relevance 0.07 Pain Relevance 0
Overexpression of ADAR1 and ADAR2 in GBM cell line results in a decreased proliferation rate, suggesting that reduced A-to-I editing in brain tumors is involved in the pathogenesis of cancer [59].
Gene_expression (Overexpression) of ADAR2 in brain associated with cancer and brain tumor
19) Confidence 0.61 Published 2009 Journal Mol Brain Section Body Doc Link PMC2694175 Disease Relevance 1.29 Pain Relevance 0
In addition, expression of ADAR1 and ADAR2 does not correspond with editing frequencies of specific target sites in the 5-HT2CR mRNA.
Gene_expression (expression) of ADAR2
20) Confidence 0.61 Published 2009 Journal Mol Brain Section Body Doc Link PMC2694175 Disease Relevance 0 Pain Relevance 0

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