INT272359

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Context Info
Confidence 0.55
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.47
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mRNA processing (Adar) nucleolus (Adar) RNA binding (Adar)
nucleus (Adar) intracellular (Adar) DNA binding (Adar)
Anatomy Link Frequency
brain 2
Adar (Mus musculus)
Pain Link Frequency Relevance Heat
Serotonin 42 40.32 Quite Low
Glutamate receptor 9 38.20 Quite Low
hyperexcitability 6 20.72 Low Low
agonist 3 18.44 Low Low
adenocard 33 5.00 Very Low Very Low Very Low
Glutamate 30 5.00 Very Low Very Low Very Low
ischemia 15 5.00 Very Low Very Low Very Low
Action potential 15 5.00 Very Low Very Low Very Low
potassium channel 12 5.00 Very Low Very Low Very Low
depression 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Brain Tumor 6 98.76 Very High Very High Very High
Anaplastic Astrocytoma 9 97.44 Very High Very High Very High
Glioblastoma 15 95.00 High High
Malignant Neoplastic Disease 6 94.68 High High
Cancer 27 93.56 High High
Death 15 69.28 Quite High
Targeted Disruption 21 68.40 Quite High
Neurodegenerative Disease 6 62.24 Quite High
Disease 12 45.00 Quite Low
Epilepsy 27 28.80 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Overexpression of ADAR1 is shown to inhibit the editing activity of ADAR2 in pediatric astrocytoma, and ADAR1 could co-immunoprecipitate with ADAR2, suggesting a possible mechanism of inhibition via sequestering ADAR2 by ADAR1 in a heterodimer formation [37].
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of ADAR1 associated with anaplastic astrocytoma
1) Confidence 0.55 Published 2009 Journal Mol Brain Section Body Doc Link PMC2694175 Disease Relevance 0.17 Pain Relevance 0
Overexpression of ADAR1 and ADAR2 in GBM cell line results in a decreased proliferation rate, suggesting that reduced A-to-I editing in brain tumors is involved in the pathogenesis of cancer [59].
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of ADAR1 in brain associated with cancer and brain tumor
2) Confidence 0.55 Published 2009 Journal Mol Brain Section Body Doc Link PMC2694175 Disease Relevance 1.24 Pain Relevance 0
A separate study by Hang et al finds that while expression level of ADAR2 mRNA markedly increases, that of ADAR1 mRNA remains constant during development [45].
Positive_regulation (increases) of Gene_expression (expression) of ADAR1
3) Confidence 0.40 Published 2009 Journal Mol Brain Section Body Doc Link PMC2694175 Disease Relevance 0.06 Pain Relevance 0

General Comments

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