INT27236

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Context Info
Confidence 0.53
First Reported 1989
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 17
Total Number 17
Disease Relevance 10.79
Pain Relevance 1.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (F13a1) transferase activity, transferring acyl groups (F13a1) cytoplasm (F13a1)
Anatomy Link Frequency
platelet 2
blood 1
plasma 1
hemolymph 1
tooth 1
F13a1 (Mus musculus)
Pain Link Frequency Relevance Heat
cva 13 99.64 Very High Very High Very High
anesthesia 8 99.48 Very High Very High Very High
headache 11 98.76 Very High Very High Very High
epidural 5 96.40 Very High Very High Very High
Pain 6 88.96 High High
Angina 2 85.92 High High
abdominal pain 4 80.88 Quite High
antiepileptic Drug 7 68.96 Quite High
carbamazepine 4 66.72 Quite High
depression 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Purpura 18 99.92 Very High Very High Very High
Syndrome 15 99.90 Very High Very High Very High
Emergencies 2 99.88 Very High Very High Very High
Cv General 3 Under Development 9 99.64 Very High Very High Very High
Chronic Subdural Hematoma 10 99.52 Very High Very High Very High
Splenic Infarction 1 99.48 Very High Very High Very High
Coronary Artery Disease 1 99.08 Very High Very High Very High
Anaemia 5 99.06 Very High Very High Very High
Proteinuria 16 98.88 Very High Very High Very High
"congenital, Hereditary, And Neonatal Diseases And Abnormalities" 1 98.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Among the patients with severe abdominal symptoms, factor XIII activity was significantly decreased in patients with significant proteinuria compared to other patients without significant proteinuria.
Negative_regulation (creased i) of factor XIII associated with proteinuria
1) Confidence 0.53 Published 2002 Journal Eur. J. Pediatr. Section Abstract Doc Link 12014385 Disease Relevance 1.32 Pain Relevance 0.07
The risk factors in a univariate analysis were severe abdominal symptoms, persistent purpura, decreased factor XIII activity, treatment with steroids, and treatment with factor XIII concentrate.
Negative_regulation (creased f) of factor XIII associated with purpura
2) Confidence 0.53 Published 2002 Journal Eur. J. Pediatr. Section Abstract Doc Link 12014385 Disease Relevance 1.45 Pain Relevance 0.08
The authors report on three young men with a deficiency in coagulation factor XIII (FXIII) who underwent surgery for chronic SDHs.
Negative_regulation (deficiency) of factor XIII associated with chronic subdural hematoma
3) Confidence 0.49 Published 2005 Journal J. Neurosurg. Section Abstract Doc Link 16028774 Disease Relevance 0.78 Pain Relevance 0.05
At the active stage of UC, a marked increase in platelet count and fibrinogen concentration, and a marked decrease in Factor XIII activity level were observed.
Negative_regulation (decrease) of Factor XIII in platelet associated with inflammatory bowel disease
4) Confidence 0.48 Published 1989 Journal Blut Section Abstract Doc Link 2765674 Disease Relevance 0.46 Pain Relevance 0.09
Anesthetic management of a patient with Ehlers-Danlos syndrome and factor XIII deficiency was reviewed.
Negative_regulation (deficiency) of factor XIII associated with syndrome
5) Confidence 0.41 Published 1989 Journal Masui Section Abstract Doc Link 2585722 Disease Relevance 0.52 Pain Relevance 0.16
Because of factor XIII deficiency, the patient experienced severe gingival bleeding after tooth extraction.
Negative_regulation (deficiency) of factor XIII in tooth associated with hemorrhage
6) Confidence 0.41 Published 1999 Journal Rinsho Ketsueki Section Abstract Doc Link 10496039 Disease Relevance 1.63 Pain Relevance 0.16
CONCLUSION: We speculate that one of the possible mechanisms of cephalhematoma expansion without blood coagulation defects might be acquired factor XIII deficiency from severe hemorrhage in a hematoma.


Negative_regulation (deficiency) of factor XIII in blood
7) Confidence 0.41 Published 2003 Journal Surg Neurol Section Body Doc Link 12900121 Disease Relevance 0 Pain Relevance 0
[Anesthesia for a patient with Ehlers-Danlos syndrome and factor XIII deficiency].
Negative_regulation (deficiency) of factor XIII associated with anesthesia and syndrome
8) Confidence 0.41 Published 1989 Journal Masui Section Title Doc Link 2585722 Disease Relevance 0.56 Pain Relevance 0.30
[Thrombelastometric detection of factor XIII deficiency].
Negative_regulation (deficiency) of factor XIII associated with anesthesia
9) Confidence 0.37 Published 2008 Journal Anaesthesist Section Title Doc Link 18338137 Disease Relevance 0.27 Pain Relevance 0.10
Spontaneous chronic subdural hematomas in young adults with a deficiency in coagulation factor XIII.
Negative_regulation (deficiency) of factor XIII associated with chronic subdural hematoma and headache
10) Confidence 0.36 Published 2005 Journal J. Neurosurg. Section Title Doc Link 16028774 Disease Relevance 0.82 Pain Relevance 0.34
An intraoperatively performed thrombelastometry with ROTEM (Pentapharm, Munich, Germany) showed an aprotonin-resistant mild fibrinolysis and suggested the presence of an isolated deficiency of coagulation factor XIII.
Negative_regulation (deficiency) of factor XIII
11) Confidence 0.32 Published 2008 Journal Anaesthesist Section Abstract Doc Link 18338137 Disease Relevance 0.27 Pain Relevance 0
The use of intracardiac laser light irradiation of blood in combined treatment was found to improve the clinical course of the illness and to have a beneficial effect on the factors of plasma haemostasis and fibrinolysis which play a pathogenetic role in the destabilization of the ischemic heart disease course, this being manifest by a significant decrease in the activity of factor XIII, platelet factor 4, and an increase in fibrinolysis.
Negative_regulation (decrease) of factor XIII in plasma associated with coronary artery disease
12) Confidence 0.21 Published 1994 Journal Lik. Sprava Section Abstract Doc Link 7831873 Disease Relevance 0.26 Pain Relevance 0.16
Subcutaneous injection of crude hemolymph and some chromatographic fractions of LA induce a decrease in fibrinogen, plasminogen and factor XIII.
Negative_regulation (decrease) of factor XIII in hemolymph
13) Confidence 0.05 Published 2000 Journal Biochimie Section Abstract Doc Link 11086223 Disease Relevance 0.44 Pain Relevance 0.07
Factor XIII (F XIII) deficiency is a rare autosomal recessive congenital disorder that can cause spontaneous subdural or epidural hematomas.
Negative_regulation (deficiency) of Factor XIII associated with hematoma, epidural and "congenital, hereditary, and neonatal diseases and abnormalities"
14) Confidence 0.05 Published 2010 Journal J Emerg Med Section Abstract Doc Link 18514462 Disease Relevance 0.55 Pain Relevance 0.16
Intravenous injection of factor XIII proteolytic/urokinase-like activity induce a dose-dependent thrombolysis with a decrease in plasmatic factor XIII without hemorrhagic manifestations.
Negative_regulation (decrease) of factor XIII associated with cva
15) Confidence 0.04 Published 2000 Journal Biochimie Section Abstract Doc Link 11086223 Disease Relevance 0.27 Pain Relevance 0.05
VPA-associated factor XIII deficiency has been described in a few patients, with the involvement of VPA not in doubt, because of recovery after treatment and the rarity of double mutation.
Negative_regulation (deficiency) of factor XIII
16) Confidence 0.02 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2926634 Disease Relevance 0.47 Pain Relevance 0.07
Hematological tests show: mild anemia with leucocytosis; prolonged PT, PTT and ThT; decreased fibrinogen, factor V, factor XIII, plasminogen and alpha2-antiplasmin levels; increased factor VIII:c, von Willebrand factor, and FDPs/D-dimers levels with normal ATIII and platelets.
Negative_regulation (decreased) of factor XIII in platelets associated with anaemia
17) Confidence 0.02 Published 2000 Journal Biochimie Section Abstract Doc Link 11086223 Disease Relevance 0.72 Pain Relevance 0.14

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