INT272363

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Context Info
Confidence 0.26
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.76
Pain Relevance 0.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mRNA processing (Adar, Adarb1) nucleolus (Adar, Adarb1) RNA binding (Adar, Adarb1)
nucleus (Adar, Adarb1) intracellular (Adar, Adarb1) nucleoplasm (Adarb1)
Adar (Mus musculus)
Adarb1 (Mus musculus)
Pain Link Frequency Relevance Heat
Serotonin 43 91.36 High High
fluoxetine 31 84.88 Quite High
antidepressant 3 72.68 Quite High
depression 7 70.96 Quite High
adenocard 25 5.00 Very Low Very Low Very Low
Glutamate 20 5.00 Very Low Very Low Very Low
Endep 17 5.00 Very Low Very Low Very Low
Hippocampus 16 5.00 Very Low Very Low Very Low
ischemia 10 5.00 Very Low Very Low Very Low
Action potential 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Anaplastic Astrocytoma 6 99.88 Very High Very High Very High
Targeted Disruption 23 82.28 Quite High
Schizophrenia 11 79.60 Quite High
Urological Neuroanatomy 1 78.92 Quite High
Depression 7 70.96 Quite High
Suicidal Behaviour 3 69.24 Quite High
Congenital Anomalies 2 67.48 Quite High
Convulsion 9 12.32 Low Low
Motor Neuron Diseases 28 5.00 Very Low Very Low Very Low
Cancer 19 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, it is difficult to reconcile any mechanistic hypothesis with the observed changes, given the known activities and specificities of ADAR1 and ADAR2.
ADAR1 Binding (specificities) of ADAR2
1) Confidence 0.26 Published 2010 Journal Nucleic Acids Research Section Body Doc Link PMC2879535 Disease Relevance 0.43 Pain Relevance 0.36
Therefore, it is possible that a heterodimer of ADAR1 and ADAR2 may result in a non-functional enzyme that could neither edit ADAR1 nor ADAR2 substrates.
ADAR1 Binding (heterodimer) of ADAR2
2) Confidence 0.25 Published 2009 Journal Mol Brain Section Body Doc Link PMC2694175 Disease Relevance 0.15 Pain Relevance 0
Overexpression of ADAR1 is shown to inhibit the editing activity of ADAR2 in pediatric astrocytoma, and ADAR1 could co-immunoprecipitate with ADAR2, suggesting a possible mechanism of inhibition via sequestering ADAR2 by ADAR1 in a heterodimer formation [37].
ADAR1 Binding (immunoprecipitate) of ADAR2 associated with anaplastic astrocytoma
3) Confidence 0.25 Published 2009 Journal Mol Brain Section Body Doc Link PMC2694175 Disease Relevance 0.18 Pain Relevance 0

General Comments

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