INT272376

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.62
First Reported 2009
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 12
Total Number 14
Disease Relevance 0.47
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Trpv6) transmembrane transport (Trpv6)
Anatomy Link Frequency
uterine 8
uterus 2
glandular epithelial cells 1
placenta 1
Trpv6 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 104 100.00 Very High Very High Very High
member 8 26 93.36 High High
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Kidney Stones 16 89.52 High High
Targeted Disruption 56 78.40 Quite High
Body Weight 4 9.64 Low Low
Endometriosis (extended) 13 5.00 Very Low Very Low Very Low
Volume Depletion And Dehydration 2 5.00 Very Low Very Low Very Low
Hematuria 1 5.00 Very Low Very Low Very Low
Hypercalcemia 1 5.00 Very Low Very Low Very Low
Apoptosis 1 5.00 Very Low Very Low Very Low
Weight Gain 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As shown in Fig 6C, treatment with ICI significantly reduced uterine TRPV6 expression, whereas RU did not affect uterine TRPV6 transcription levels in the mouse uterus.
Neg (not) Regulation (affect) of TRPV6 in uterine
1) Confidence 0.62 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2694200 Disease Relevance 0 Pain Relevance 0
Effects of sex steroid receptor antagonists on uterine and placental TRPV6 mRNA in a rat and mouse model
Regulation (Effects) of TRPV6 mRNA in uterine associated with antagonist
2) Confidence 0.62 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2694200 Disease Relevance 0 Pain Relevance 0.05
These results suggest that TRPV6 may be distinctly regulated by different sex steroids, progesterone in rats and estrogen in mice, in spite of shared similarities in their chromosomal make-up [12,20,39].
Regulation (regulated) of TRPV6
3) Confidence 0.62 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2694200 Disease Relevance 0 Pain Relevance 0
In both rodents, uterine TRPV6 immunoreactivity was observed in luminal and glandular epithelial cells, and in the placenta TRPV6 was detected in the labyrinth and spongy zone.
Regulation (immunoreactivity) of TRPV6 in glandular epithelial cells
4) Confidence 0.62 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2694200 Disease Relevance 0 Pain Relevance 0
As shown in Fig 6C, treatment with ICI significantly reduced uterine TRPV6 expression, whereas RU did not affect uterine TRPV6 transcription levels in the mouse uterus.
Regulation (uterine) of TRPV6 in uterine
5) Confidence 0.45 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2694200 Disease Relevance 0 Pain Relevance 0
In addition, TRPV6 gene was significantly down-regulated by ICI, while RU did not alter its mRNA levels in the mouse placenta (Figure 6D).
Regulation (regulated) of TRPV6 in placenta
6) Confidence 0.45 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2694200 Disease Relevance 0 Pain Relevance 0
Several previous reports described the regulation of TRPV5 and TRPV6 by vitamin D3 (15, 17-20) and estrogen (17, 21).
Regulation (regulation) of TRPV6
7) Confidence 0.39 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2923802 Disease Relevance 0.32 Pain Relevance 0
Distinct their expression patterns indicate that uterine TRPV6 is differentially regulated during the estrous cycle in rats and mice.
Regulation (regulated) of TRPV6 in uterine
8) Confidence 0.27 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2694200 Disease Relevance 0 Pain Relevance 0
In addition, uterine TRPV6 mRNA is only expressed in placenta-unattached areas of the uterus, and uterine TRPV6 immunoreactivity was observed in luminal and glandular epithelial cells.
Regulation (immunoreactivity) of TRPV6 in uterine
9) Confidence 0.27 Published 2009 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC2694200 Disease Relevance 0 Pain Relevance 0.11
Although ICI partially down-regulated TRPV6 gene in the rat uterus, progesterone and its receptor appear to primarily control uterine TRPV6 transcripts in this tissue during pregnancy.
Spec (appear) Regulation (control) of TRPV6 in uterus
10) Confidence 0.27 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2694200 Disease Relevance 0.15 Pain Relevance 0.12
Recently, uterine TRPV6 was shown to be regulated by progesterone in immature and non-pregnant rats [11], whereas its expression in a mouse model was shown to be controlled by estrogen [12].
Regulation (regulated) of TRPV6 in uterine
11) Confidence 0.27 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2694200 Disease Relevance 0 Pain Relevance 0.05
In addition, the changes in the uterine transcript levels of TRPV6 as a function of pregnancy may be largely a reflection of myometrial changes in its expression in both rats and mice.
Regulation (changes) of TRPV6 in uterine
12) Confidence 0.27 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2694200 Disease Relevance 0 Pain Relevance 0
In the present study, we investigated the expression and regulation of uterine and placental TRPV6 during gestation in rodents.
Spec (investigated) Regulation (regulation) of TRPV6 in uterine
13) Confidence 0.24 Published 2009 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC2694200 Disease Relevance 0 Pain Relevance 0.09
In addition, uterine TRPV6 mRNA is only expressed in placenta-unattached areas of the uterus, and uterine TRPV6 immunoreactivity was observed in luminal and glandular epithelial cells.
Regulation (immunoreactivity) of TRPV6 in uterus
14) Confidence 0.09 Published 2009 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC2694200 Disease Relevance 0 Pain Relevance 0.11

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox