INT272414

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Context Info
Confidence 0.37
First Reported 2006
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 9
Total Number 11
Disease Relevance 12.88
Pain Relevance 0.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
eyes 8
outflow 2
capsule 2
NARFL (Homo sapiens)
Pain Link Frequency Relevance Heat
corticosteroid 8 98.04 Very High Very High Very High
sSRI 33 95.20 Very High Very High Very High
Inflammation 48 93.88 High High
Central nervous system 22 93.64 High High
fibrosis 6 78.00 Quite High
cva 5 69.96 Quite High
glial activation 2 67.28 Quite High
ischemia 17 64.08 Quite High
fluoxetine 4 56.32 Quite High
tetrodotoxin 5 55.88 Quite High
Disease Link Frequency Relevance Heat
Ocular Hypertension 783 100.00 Very High Very High Very High
Glaucoma 239 99.32 Very High Very High Very High
Fibrosis 8 98.90 Very High Very High Very High
Pressure And Volume Under Development 21 96.20 Very High Very High Very High
Diabetic Macular Edema 16 96.20 Very High Very High Very High
Blister 7 95.40 Very High Very High Very High
Uveitis 10 95.12 Very High Very High Very High
INFLAMMATION 48 93.88 High High
Disease 24 88.16 High High
Optic Nerve Injuries 35 86.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The significant increase in IOP levels observed in the first hour in our cases was probably due to the volume-effect of the injected IVTA; only 8.8% of the eyes showed a moderately elevated IOP in the first hour postinjection.
Spec (probably) Positive_regulation (due) of Positive_regulation (increase) of IOP in eyes associated with ocular hypertension
1) Confidence 0.37 Published 2008 Journal Clinical ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2698684 Disease Relevance 1.35 Pain Relevance 0
Repeated IVTA injections in 21 eyes did not result in an increase in IOP.


Neg (not) Positive_regulation (result) of Positive_regulation (increase) of IOP in eyes associated with ocular hypertension
2) Confidence 0.37 Published 2008 Journal Clinical ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2698684 Disease Relevance 1.16 Pain Relevance 0.05
Gillies and colleagues (2006) reported an incidence of IOP elevation (increased by >5 mm Hg) of 68%, significantly higher than observed in previous studies, and rates of topical treatment and glaucoma surgery of 44% and 6%, respectively.
Positive_regulation (increased) of Positive_regulation (elevation) of IOP associated with glaucoma and ocular hypertension
3) Confidence 0.37 Published 2008 Journal Clinical ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2698684 Disease Relevance 1.22 Pain Relevance 0
Corticosteroids are known to elevate the IOP by all routes of administration, but topical use of potent steroids causes IOP elevation in one-third of all eyes treated (Skuta 1996).
Positive_regulation (causes) of Positive_regulation (elevation) of IOP in eyes associated with corticosteroid and ocular hypertension
4) Confidence 0.37 Published 2008 Journal Clinical ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2698684 Disease Relevance 0.78 Pain Relevance 0.05
However there is conflicting evidence about the rate of an osmolarity decrease that can induce an increase in IOP during hemodialysis.
Positive_regulation (induce) of Positive_regulation (increase) of IOP associated with ocular hypertension
5) Confidence 0.30 Published 2006 Journal Korean Journal of Ophthalmology : KJO Section Body Doc Link PMC2908824 Disease Relevance 1.36 Pain Relevance 0
Masuda et al.7 reported that Argon laser trabeculoplasty successfully controlled the IOP elevation in exfoliative glaucoma patients showing intradialytic IOP elevation, while Choong et al.6 reported that bilateral IOP elevation after hemodialysis stabilized with topical ?
Positive_regulation (bilateral) of Positive_regulation (elevation) of IOP associated with glaucoma and ocular hypertension
6) Confidence 0.21 Published 2006 Journal Korean Journal of Ophthalmology : KJO Section Body Doc Link PMC2908824 Disease Relevance 1.57 Pain Relevance 0.11
Moreover, in comparison to normal eyes, this material is significantly greater in cases of POAG and of intermittent narrow-angle glaucoma [83], suggesting that the enhanced resistance to the outflow observed in elderly patients and, at highest extent, in the subjects suffering from the two above mentioned forms of glaucoma, represents one of the mechanism leading to IOP increase.
Positive_regulation (leading) of Positive_regulation (increase) of IOP in outflow associated with glaucoma and ocular hypertension
7) Confidence 0.07 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2701282 Disease Relevance 0.95 Pain Relevance 0.16
Our study showed that both the APACG group and the CPACG group had significantly higher IOP levels and corresponding significantly higher flare value and cell counts than the healthy control group, implying that IOP elevation might be responsible for the changes of the BAB in the two PACG groups.
Spec (might) Positive_regulation (responsible) of Positive_regulation (elevation) of IOP associated with glaucoma and ocular hypertension
8) Confidence 0.06 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2965576 Disease Relevance 1.48 Pain Relevance 0.14
The IOP elevation, especially a dramatic IOP elevation, might be the factor responsible for the change of BAB in eyes with PACG.



Positive_regulation (elevation) of Positive_regulation (elevation) of IOP in eyes associated with glaucoma and ocular hypertension
9) Confidence 0.05 Published 2010 Journal Molecular Vision Section Abstract Doc Link PMC2965576 Disease Relevance 0.70 Pain Relevance 0.08
The fibrotic capsule formed is resistant to aqueous flow, and thus results in an IOP elevation.13,16,17
Positive_regulation (results) of Positive_regulation (elevation.13,16,17) of IOP in capsule associated with fibrosis and ocular hypertension
10) Confidence 0.03 Published 2009 Journal Korean Journal of Ophthalmology : KJO Section Body Doc Link PMC2694298 Disease Relevance 1.18 Pain Relevance 0.03
Differences in species as well as the method of inducing elevated IOP used in Wang et al.’s study may account for the observed differences in the microglial activation in the rodent LGN [49].
Positive_regulation (inducing) of Positive_regulation (elevated) of IOP associated with ocular hypertension
11) Confidence 0.01 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2773743 Disease Relevance 1.13 Pain Relevance 0.23

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