INT27242

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Context Info
Confidence 0.75
First Reported 1983
Last Reported 2011
Negated 15
Speculated 3
Reported most in Abstract
Documents 153
Total Number 156
Disease Relevance 98.77
Pain Relevance 12.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (PGR) enzyme binding (PGR) DNA binding (PGR)
cell-cell signaling (PGR) cytoplasm (PGR) signal transduction (PGR)
Anatomy Link Frequency
endometrium 6
myometrium 3
epithelial cells 3
mammary gland 2
arm 2
PGR (Homo sapiens)
Pain Link Frequency Relevance Heat
depression 14 100.00 Very High Very High Very High
fibrosis 21 99.88 Very High Very High Very High
endometriosis 1698 99.80 Very High Very High Very High
withdrawal 56 99.62 Very High Very High Very High
Inflammation 718 99.40 Very High Very High Very High
Breakthrough pain 64 99.00 Very High Very High Very High
Clonidine 12 98.36 Very High Very High Very High
antagonist 430 96.44 Very High Very High Very High
Gabapentin 3 96.34 Very High Very High Very High
carbamazepine 14 95.90 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 3926 100.00 Very High Very High Very High
Breast Cancer 3163 100.00 Very High Very High Very High
Inflammatory Breast Neoplasms 745 100.00 Very High Very High Very High
Advanced Or Metastatic Breast Cancer 463 100.00 Very High Very High Very High
Leukemia 43 100.00 Very High Very High Very High
Depression 21 100.00 Very High Very High Very High
Skin Cancer 16 100.00 Very High Very High Very High
Disorders Of Creatine Metabolism 13 100.00 Very High Very High Very High
Fibrosis 22 99.88 Very High Very High Very High
Chordoma 131 99.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, progesterone-receptor was detected in the pulmonary tissue obtained at open lung biopsy.
Gene_expression (detected) of progesterone-receptor in lung
1) Confidence 0.75 Published 1989 Journal Nihon Kyobu Shikkan Gakkai Zasshi Section Abstract Doc Link 2585908 Disease Relevance 0.66 Pain Relevance 0.07
The expression of ER and PR in these cell lines has been re-examined to determine their presence in lymph node metastases from patients who did not receive any kind of endocrine therapy and in distant metastases obtained from patients who failed endocrine treatment.
Gene_expression (expression) of PR in lymph node associated with metastasis
2) Confidence 0.75 Published 1997 Journal J. Pathol. Section Abstract Doc Link 9349240 Disease Relevance 0.42 Pain Relevance 0
Controversial results exist on the expression of ER and PR in epithelial cells of the prostate.
Gene_expression (expression) of PR in epithelial cells
3) Confidence 0.75 Published 1997 Journal J. Pathol. Section Abstract Doc Link 9349240 Disease Relevance 0.30 Pain Relevance 0
ER and PR expression in LNCaP, PC-3, and DU-145 cells was assessed by means of the reverse transcriptase-polymerase chain reaction, ligand binding assays, and immunohistochemistry.
Gene_expression (expression) of PR in PC-3
4) Confidence 0.75 Published 1997 Journal J. Pathol. Section Abstract Doc Link 9349240 Disease Relevance 0.55 Pain Relevance 0.06
A radial stiffness modulus (ER) was determined by the slope of the PR vs log h plots before and after pacing.
Spec (determined) Gene_expression (slope) of PR in radial
5) Confidence 0.68 Published 1983 Journal Circulation Section Abstract Doc Link 6848219 Disease Relevance 0.68 Pain Relevance 0.28
The inability of endometriotic stromal cells to produce progesterone-induced paracrine factors that stimulate 17beta-HSD-2 may be due to the lack of PR-B and very low levels of progesterone receptor A (PR-A) observed in vivo in endometriotic tissue.
Neg (lack) Gene_expression (lack) of progesterone receptor in stromal cells associated with endometriosis
6) Confidence 0.65 Published 2006 Journal Mol. Cell. Endocrinol. Section Abstract Doc Link 16406281 Disease Relevance 0.92 Pain Relevance 0.41
Tamoxifen therapy is of greatest benefit in patients whose primary lesions are estrogen- and progesterone-receptor positive, but lesser yet still significant benefits are seen in receptor-negative patients.
Gene_expression (positive) of progesterone-receptor
7) Confidence 0.65 Published 1994 Journal Cancer Section Abstract Doc Link 8087784 Disease Relevance 0.46 Pain Relevance 0.06
PR expression was significantly higher in secondary post-surgical IC (p = 0.04).
Gene_expression (expression) of PR associated with carcinoma
8) Confidence 0.65 Published 2003 Journal Breast Cancer Res. Treat. Section Abstract Doc Link 12725414 Disease Relevance 1.55 Pain Relevance 0.16
The significant decrease in PgR expression with letrozole remained significant in the ER+, HER2+ subpopulation.
Gene_expression (expression) of PgR
9) Confidence 0.64 Published 2007 Journal Breast Cancer Res Treat Section Body Doc Link PMC2001223 Disease Relevance 0.35 Pain Relevance 0
Letrozole, but not tamoxifen, significantly reduced the expression of estrogen-regulated proteins PgR and TFF1 [38].
Gene_expression (expression) of PgR
10) Confidence 0.64 Published 2007 Journal Breast Cancer Res Treat Section Body Doc Link PMC2001223 Disease Relevance 0.38 Pain Relevance 0
Interestingly, letrozole was effective even in marginally ER+ tumors and, unlike tamoxifen, consistently reduced the expression from estrogen-regulated genes (progesterone receptor and trefoil factor 1).
Gene_expression (expression) of progesterone receptor associated with cancer
11) Confidence 0.64 Published 2007 Journal Breast Cancer Res Treat Section Abstract Doc Link PMC2001223 Disease Relevance 0.48 Pain Relevance 0
The Allred histopathological score was applied to further assess the level of ER and PgR expression in both the baseline and surgical specimens [42].To explore relationships between ER and PgR expression levels and response to treatment [37].To examine the relationship between the expression of HER1 and HER2 and the likelihood of primary response [37].
Gene_expression (expression) of PgR
12) Confidence 0.64 Published 2007 Journal Breast Cancer Res Treat Section Body Doc Link PMC2001223 Disease Relevance 0.31 Pain Relevance 0
Average tumor PgR expression decreased dramatically on letrozole treatment (P = 0.0001), and only 4.4% of surgical specimens exhibited an Allred score of between six and eight for PgR expression.
Gene_expression (expression) of PgR associated with cancer
13) Confidence 0.64 Published 2007 Journal Breast Cancer Res Treat Section Body Doc Link PMC2001223 Disease Relevance 0.37 Pain Relevance 0
The Allred histopathological score was applied to further assess the level of ER and PgR expression in both the baseline and surgical specimens [42].To explore relationships between ER and PgR expression levels and response to treatment [37].To examine the relationship between the expression of HER1 and HER2 and the likelihood of primary response [37].
Gene_expression (expression) of PgR
14) Confidence 0.64 Published 2007 Journal Breast Cancer Res Treat Section Body Doc Link PMC2001223 Disease Relevance 0.27 Pain Relevance 0
Average tumor PgR expression decreased dramatically on letrozole treatment (P = 0.0001), and only 4.4% of surgical specimens exhibited an Allred score of between six and eight for PgR expression.
Gene_expression (expression) of PgR associated with cancer
15) Confidence 0.64 Published 2007 Journal Breast Cancer Res Treat Section Body Doc Link PMC2001223 Disease Relevance 0.36 Pain Relevance 0
In contrast, changes in PgR expression with tamoxifen therapy were not consistent, with both increases and decreases in expression frequently observed in the overall and ER+, HER2+ subpopulations.
Gene_expression (expression) of PgR
16) Confidence 0.64 Published 2007 Journal Breast Cancer Res Treat Section Body Doc Link PMC2001223 Disease Relevance 0.34 Pain Relevance 0
Patients unable to identify a dose that produced satisfactory PR and those not completing the titration within 2 weeks were discontinued from the study.
Gene_expression (produced) of PR
17) Confidence 0.58 Published 2010 Journal Annals of Oncology Section Body Doc Link PMC2875549 Disease Relevance 0.63 Pain Relevance 0.71
Patients who identified a dose that produced satisfactory PR for at least two target breakthrough pain episodes were eligible to enter the double-blind crossover period.
Gene_expression (produced) of PR associated with pain and breakthrough pain
18) Confidence 0.58 Published 2010 Journal Annals of Oncology Section Body Doc Link PMC2875549 Disease Relevance 0.60 Pain Relevance 0.67
We evaluated endometrial and mammary gland histopathology and morphometry and used immunohistochemistry to evaluate cell proliferation and expression of estrogen receptor alpha and progesterone receptor (PR).
Gene_expression (expression) of PR in mammary gland
19) Confidence 0.58 Published 2001 Journal Toxicol Pathol Section Abstract Doc Link 11215689 Disease Relevance 0.49 Pain Relevance 0.10
Tamoxifen induced endometrial polyps, cystic hyperplasia, stromal fibrosis, and PR expression but not Ki-67 expression.
Gene_expression (expression) of PR associated with fibrosis, endometriosis (extended) and hyperplasia
20) Confidence 0.58 Published 2001 Journal Toxicol Pathol Section Abstract Doc Link 11215689 Disease Relevance 0.57 Pain Relevance 0.14

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