INT27243

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Context Info
Confidence 0.68
First Reported 1989
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 13
Total Number 25
Disease Relevance 26.71
Pain Relevance 2.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (SPINK1)
Anatomy Link Frequency
acinar cells 2
juvenile 1
SPINK1 (Homo sapiens)
SPINK1 - N34S (3)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 201 100.00 Very High Very High Very High
Inflammation 62 99.84 Very High Very High Very High
fibrosis 26 96.72 Very High Very High Very High
alcohol 24 71.80 Quite High
abdominal pain 3 69.64 Quite High
cytokine 18 67.44 Quite High
imagery 2 43.20 Quite Low
Pain 1 26.52 Quite Low
Inflammatory response 2 20.52 Low Low
palliative 13 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pancreatitis 458 100.00 Very High Very High Very High
Apoptosis 16 100.00 Very High Very High Very High
INFLAMMATION 64 99.84 Very High Very High Very High
Pancreatic Cancer 7 99.38 Very High Very High Very High
Cancer 400 99.26 Very High Very High Very High
Colon Cancer 444 99.24 Very High Very High Very High
Renal Cancer 52 99.00 Very High Very High Very High
Breast Cancer 13 98.96 Very High Very High Very High
Malignant Neoplastic Disease 39 98.60 Very High Very High Very High
Disease 345 98.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The origin of the tumor could not be found, but pancreatic cancer was suspected on the basis of elevated CEA and PSTI levels.
Positive_regulation (elevated) of PSTI associated with cancer and pancreatic cancer
1) Confidence 0.68 Published 1995 Journal Hinyokika Kiyo Section Abstract Doc Link 7900570 Disease Relevance 1.26 Pain Relevance 0.07
However, in that study, it was also shown that an impaired renal function could contribute to elevated s-TATI levels in patients with renal cancer.
Positive_regulation (elevated) of s-TATI associated with renal cancer
2) Confidence 0.53 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2946315 Disease Relevance 0.80 Pain Relevance 0
Solakidi et al suggested that leakage from the tumour cells into the circulation might be the mechanism behind elevated s-TATI levels [15], but the lack of a correlation between s-TATI and t-TATI in this study implies that leakage from the tumour into the circulation is not a major cause of elevated s-TATI levels.
Neg (not) Positive_regulation (cause) of s-TATI associated with cancer
3) Confidence 0.53 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2946315 Disease Relevance 1.46 Pain Relevance 0.04
For each study, we initially evaluated the association of SPINK1 N34S high-risk haplotype with CP separately.
Positive_regulation (haplotype) of SPINK1 (N34S) associated with chronic pancreatitis
4) Confidence 0.50 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2289874 Disease Relevance 0.27 Pain Relevance 0.27
The third gene that was postulated to be associated with ICP is the serine protease inhibitor Kazal type 1 (SPINK1).
Positive_regulation (postulated) of SPINK1 associated with chronic pancreatitis
5) Confidence 0.50 Published 2003 Journal BMC Gastroenterol Section Body Doc Link PMC317302 Disease Relevance 1.31 Pain Relevance 0.76
Recently an association was identified between idiopathic pancreatitis in the USA and Europe and mutations in the serine protease inhibitor, Kazal type 1 (SPINK1) gene (previously termed pancreatic secretory trypsin inhibitor, PSTI).
Positive_regulation (termed) of PSTI associated with pancreatitis
6) Confidence 0.49 Published 2001 Journal Pancreatology Section Abstract Doc Link 12120202 Disease Relevance 0.87 Pain Relevance 0.08
SPINK1 is an acute phase protein whose gene expression and protein concentrations are markedly upregulated by inflammation [16], [17], [18].
Positive_regulation (upregulated) of SPINK1 associated with inflammation
7) Confidence 0.47 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2289874 Disease Relevance 1.12 Pain Relevance 0.74
Association analysis of the total cohort after dichotomization based on N34S SPINK1 and L26V CTSB mutation status showed comparable allele and genotype frequencies for rs7903146 in both groups, indicating that co-existence of these variants does not increase the risk of developing diabetes in these patients (table 4).
Positive_regulation (based) of SPINK1 (N34S) associated with diabetes mellitus
8) Confidence 0.42 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2529279 Disease Relevance 1.29 Pain Relevance 0
In this study, we have shown that elevated levels of s-TATI independently predict an adverse outcome in CRC patients and this was also the case in separate analysis of patients with Stage II and III disease.
Positive_regulation (elevated) of s-TATI associated with colon cancer and disease
9) Confidence 0.38 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2946315 Disease Relevance 0.63 Pain Relevance 0
However, in that study, it was also shown that an impaired renal function could contribute to elevated s-TATI levels in patients with renal cancer.
Positive_regulation (contribute) of s-TATI associated with renal cancer
10) Confidence 0.38 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2946315 Disease Relevance 0.80 Pain Relevance 0
Satake et al found elevated s-TATI concentrations in CRC patients, but the results were not considered to be of sufficient diagnostic value for clinical use [12].
Positive_regulation (elevated) of s-TATI associated with colon cancer
11) Confidence 0.38 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2946315 Disease Relevance 1.61 Pain Relevance 0
Solakidi et al suggested that leakage from the tumour cells into the circulation might be the mechanism behind elevated s-TATI levels [15], but the lack of a correlation between s-TATI and t-TATI in this study implies that leakage from the tumour into the circulation is not a major cause of elevated s-TATI levels.
Positive_regulation (elevated) of s-TATI associated with cancer
12) Confidence 0.38 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2946315 Disease Relevance 1.28 Pain Relevance 0.04
Increased levels of s-TATI were associated with a reduced DFS (HR = 2.00; 95% CI 1.40-2.84, P < 0.001) and OS (HR = 2.40; 95% CI 1.74-3.33, P < 0.001).
Positive_regulation (Increased) of s-TATI
13) Confidence 0.36 Published 2010 Journal BMC Cancer Section Abstract Doc Link PMC2946315 Disease Relevance 0.78 Pain Relevance 0
Elevated levels of s-TATI can also be detected temporarily in some non-malignant conditions, especially in pancreatitis [18], and in severe inflammatory diseases, injuries, and sepsis [12,19].
Positive_regulation (levels) of s-TATI associated with malignant neoplastic disease, inflammation, injury, pancreatitis, disease and sepsis
14) Confidence 0.36 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2946315 Disease Relevance 1.47 Pain Relevance 0.09
A transitory elevation of s-TATI levels have been found after surgery, suggesting that TATI may behave as an acute phase protein [14,17].
Positive_regulation (elevation) of s-TATI
15) Confidence 0.36 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2946315 Disease Relevance 1.48 Pain Relevance 0.09
Solakidi et al suggested that leakage from the tumour cells into the circulation might be the mechanism behind elevated s-TATI levels [15], but the lack of a correlation between s-TATI and t-TATI in this study implies that leakage from the tumour into the circulation is not a major cause of elevated s-TATI levels.
Positive_regulation (elevated) of s-TATI associated with cancer
16) Confidence 0.36 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2946315 Disease Relevance 1.45 Pain Relevance 0.04
Three main mechanisms have been proposed to cause increased levels of TATI in serum; leakage from tumour-derived TATI into the circulation and as a response to tissue destruction and inflammation [16].
Positive_regulation (increased) of TATI associated with inflammation and cancer
17) Confidence 0.36 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2946315 Disease Relevance 1.57 Pain Relevance 0.08
Increased levels of s-TATI were associated with a reduced DFS (HR = 2.00; 95% CI 1.40-2.84, P < 0.001) and OS (HR = 2.40; 95% CI 1.74-3.33, P < 0.001).
Positive_regulation (levels) of s-TATI
18) Confidence 0.36 Published 2010 Journal BMC Cancer Section Abstract Doc Link PMC2946315 Disease Relevance 0.78 Pain Relevance 0
Elevation of s-TATI may also be caused by several non-malignant conditions such as severe inflammatory disease [22], pancreatitis and hepatobiliary disease [23], and tissue destruction [24,25].
Positive_regulation (Elevation) of s-TATI associated with malignant neoplastic disease, inflammation, pancreatitis and disease
19) Confidence 0.36 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2946315 Disease Relevance 1.03 Pain Relevance 0.05
TATI was found to be elevated in some subjects in all groups of patients; patients with chronic pancreatitis studied during an acute exacerbation of the disease had the highest percentage (68%) of pathological values.
Positive_regulation (elevated) of TATI associated with disease and chronic pancreatitis
20) Confidence 0.28 Published 1989 Journal Klin. Wochenschr. Section Abstract Doc Link 2586008 Disease Relevance 0.73 Pain Relevance 0.19

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