INT272430

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.66
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 2.01
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (PROK1)
Anatomy Link Frequency
endocrine gland 2
glandular epithelial cells 1
cytotrophoblast 1
PROK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 5 75.12 Quite High
cytokine 10 5.00 Very Low Very Low Very Low
Inflammation 6 5.00 Very Low Very Low Very Low
antagonist 6 5.00 Very Low Very Low Very Low
metalloproteinase 4 5.00 Very Low Very Low Very Low
Central nervous system 3 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
Intracerebroventricular 3 5.00 Very Low Very Low Very Low
IPN 3 5.00 Very Low Very Low Very Low
agonist 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 21 98.16 Very High Very High Very High
Hyperplasia 14 97.96 Very High Very High Very High
Seminoma 3 96.12 Very High Very High Very High
Testicular Cancer 3 95.40 Very High Very High Very High
Reprotox - General 1 15 94.96 High High
Disease 6 94.04 High High
Hematological Disease 14 84.48 Quite High
Neurodegenerative Disease 5 77.92 Quite High
Pain 5 75.12 Quite High
Disease Progression 3 74.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The prokineticins (PROK) are a family of multifunctional secreted proteins consisting of two members called prokineticin 1 (PROK1), also known as endocrine gland vascular endothelial growth factor, EG-VEGF (LeCouter et al., 2001; Li et al., 2001) and PROK2, also known as Bombina variegata 8, Bv8 (Mollay et al., 1999).
Localization (secreted) of EG-VEGF in endocrine gland
1) Confidence 0.66 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0.24 Pain Relevance 0.08
The amino acid sequences for PK1 and EG-VEGF are identical, and, for the purposes of this review, the term ‘PK1’ is used throughout.
Localization (used) of PK1
2) Confidence 0.59 Published 2007 Journal Trends in Endocrinology and Metabolism Section Body Doc Link PMC2694302 Disease Relevance 0 Pain Relevance 0
The expression of PK1 and PKR1 peaks in the trophoblast between 8–10 weeks of gestation, with PK1 being localized to the syncytiotrophoblast, minimal expression in the cytotrophoblast and no expression in the extravillous trophoblast [23].
Localization (localized) of PK1 in cytotrophoblast
3) Confidence 0.59 Published 2007 Journal Trends in Endocrinology and Metabolism Section Body Doc Link PMC2694302 Disease Relevance 0.24 Pain Relevance 0
The prokineticins (PROK) are a family of multifunctional secreted proteins consisting of two members called prokineticin 1 (PROK1), also known as endocrine gland vascular endothelial growth factor, EG-VEGF (LeCouter et al., 2001; Li et al., 2001) and PROK2, also known as Bombina variegata 8, Bv8 (Mollay et al., 1999).
Localization (secreted) of prokineticin 1 in endocrine gland
4) Confidence 0.57 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0.22 Pain Relevance 0.07
Also, PK1 is localized, at low levels, in glandular epithelial cells and hyperplastic benign prostate tissue, and increasing levels are detected in prostate cancer as the disease progresses [38].
Localization (localized) of PK1 in glandular epithelial cells associated with disease, reprotox - general 1 and hyperplasia
5) Confidence 0.56 Published 2007 Journal Trends in Endocrinology and Metabolism Section Body Doc Link PMC2694302 Disease Relevance 1.32 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox