INT272432

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Context Info
Confidence 0.42
First Reported 2007
Last Reported 2010
Negated 0
Speculated 3
Reported most in Body
Documents 2
Total Number 6
Disease Relevance 1.16
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (PROK1)
Anatomy Link Frequency
decidua 2
PROK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 20 95.84 Very High Very High Very High
metalloproteinase 8 72.96 Quite High
Pain 6 51.40 Quite High
Inflammation 4 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Intracerebroventricular 2 5.00 Very Low Very Low Very Low
IPN 2 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 10 99.98 Very High Very High Very High
Leukemia 4 93.24 High High
Infection 14 88.00 High High
Female Infertility 4 86.56 High High
Adhesions 8 84.96 Quite High
Hematological Disease 12 71.12 Quite High
Pain 6 51.40 Quite High
Neurodegenerative Disease 6 50.32 Quite High
Cancer 14 43.76 Quite Low
Testicular Cancer 2 35.36 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We further confirmed PROK1 regulation of IL-11 in first trimester decidua using miRNA constructs targeted to PROK1.
Regulation (regulation) of PROK1 in decidua
1) Confidence 0.42 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0 Pain Relevance 0.04
First trimester decidua was infected with one of three miRNA constructs targeting PROK1 (pLenti6/V5-EmGFP-hum-PROK1-72, -287 and a chained version-72_287) and a negative scrambled control lentivirus (as described in Evans et al., 2009).
Regulation (targeting) of PROK1 in decidua
2) Confidence 0.25 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0.09 Pain Relevance 0
In the present study, we investigated the role of PROK1–PROKR1 modulation of IL-11.
Spec (investigated) Regulation (modulation) of PROK1-PROKR1
3) Confidence 0.25 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0.19 Pain Relevance 0.10
Our findings together with others suggest that PROK1 may be important in regulating decidualization and human fertility via the expression of IL-11.
Spec (may) Regulation (important) of PROK1
4) Confidence 0.25 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0.25 Pain Relevance 0.04
Hypoxic regulation of PK1 and PKR1 is supported by the presence of a hypoxia-inducible factor (HIF-1?)
Regulation (regulation) of PK1 associated with hypoxia
5) Confidence 0.21 Published 2007 Journal Trends in Endocrinology and Metabolism Section Body Doc Link PMC2694302 Disease Relevance 0.29 Pain Relevance 0
However, factors such as human chorionic gonadotropin [43] and progesterone [39], which are known to regulate PK1 expression, are also expressed during this period and they might therefore participate in PK1 regulation.
Spec (might) Regulation (regulation) of PK1
6) Confidence 0.21 Published 2007 Journal Trends in Endocrinology and Metabolism Section Body Doc Link PMC2694302 Disease Relevance 0.33 Pain Relevance 0

General Comments

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