INT272434

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Context Info
Confidence 0.47
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 6
Disease Relevance 0.86
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (PROK1)
Anatomy Link Frequency
decidua 2
endometrium 2
PROK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 6 79.08 Quite High
cytokine 25 67.76 Quite High
metalloproteinase 10 54.84 Quite High
Inflammation 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Intracerebroventricular 1 5.00 Very Low Very Low Very Low
IPN 1 5.00 Very Low Very Low Very Low
agonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Endometriosis (extended) 6 95.64 Very High Very High Very High
Down Syndrome 5 91.84 High High
Targeted Disruption 6 90.96 High High
Pain 6 79.08 Quite High
Neurodegenerative Disease 6 78.00 Quite High
Hematological Disease 9 74.80 Quite High
Frailty 2 68.00 Quite High
Congenital Anomalies 1 62.88 Quite High
Leukemia 5 62.08 Quite High
Infection 16 45.92 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, using a specific inhibitor, INCA-6, which is known to block the interaction between calcineurin and NFAT (Roehrl et al., 2004), we have shown that inhibiting NFAT signalling can block PROK1-PROKR1 mediated expression of IL-11.
Positive_regulation (mediated) of Gene_expression (expression) of PROK1-PROKR1
1) Confidence 0.47 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0 Pain Relevance 0.06
PROK1 induced expression of IL-11 mRNA at 24 h was significantly reduced by co-treatment of tissue explants with a Gq/11 inhibitor (P < 0.05), a calcium chelator (P < 0.01) or an ERK inhibitor (P < 0.01) (Fig. 5B).
Positive_regulation (induced) of Gene_expression (expression) of PROK1
2) Confidence 0.47 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0 Pain Relevance 0
RCAN1-4 overexpression inhibits PROK1-induced expression of IL-11
Positive_regulation (overexpression) of Gene_expression (overexpression) of PROK1
3) Confidence 0.47 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0.09 Pain Relevance 0
RCAN1-4 overexpression inhibits PROK1-induced expression of IL-11
Positive_regulation (induced) of Gene_expression (expression) of PROK1
4) Confidence 0.47 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0.09 Pain Relevance 0
PROK1 and PROKR1 show differential expression across the menstrual cycle and in first trimester decidua, with increased endometrial expression of PROK1 observed in the mid-secretory phase and both PROK1 and PROKR1 increased in first trimester decidua.
Positive_regulation (increased) of Gene_expression (expression) of PROK1 in decidua
5) Confidence 0.44 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0.29 Pain Relevance 0.08
This correlates with the fact that PK1 expression is hormonally modulated, with oestrogen and progesterone increasing the expression of PK1 in the endometrium [39,43].
Positive_regulation (increasing) of Gene_expression (expression) of PK1 in endometrium
6) Confidence 0.37 Published 2007 Journal Trends in Endocrinology and Metabolism Section Body Doc Link PMC2694302 Disease Relevance 0.38 Pain Relevance 0

General Comments

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