INT272436

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.40
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 6
Disease Relevance 2.30
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (PROK1)
Anatomy Link Frequency
follicle 2
decidua 2
PROK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 20 83.12 Quite High
Inflammation 4 69.28 Quite High
Inflammatory response 2 64.68 Quite High
metalloproteinase 8 55.08 Quite High
Intracerebroventricular 2 8.16 Low Low
IPN 2 5.92 Low Low
Pain 6 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Reprotox - General 1 10 99.50 Very High Very High Very High
Cancer 14 95.16 Very High Very High Very High
Down Syndrome 4 90.32 High High
Malignant Neoplastic Disease 2 89.16 High High
Disease Progression 2 85.80 High High
Hyperplasia 12 82.24 Quite High
Carcinoma 2 79.76 Quite High
Disease 4 78.52 Quite High
Polycystic Ovary Syndrome 8 71.60 Quite High
Viral Infection 2 71.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Conversely, treatment of human decidua with a lentiviral miRNA to abolish endogenous PROK1 expression results in a significant reduction in IL-11 expression and secretion.
Negative_regulation (abolish) of Gene_expression (expression) of PROK1 in decidua
1) Confidence 0.40 Published 2010 Journal Molecular Human Reproduction Section Abstract Doc Link PMC2816169 Disease Relevance 0 Pain Relevance 0.04
Moreover, using a specific inhibitor, INCA-6, which is known to block the interaction between calcineurin and NFAT (Roehrl et al., 2004), we have shown that inhibiting NFAT signalling can block PROK1-PROKR1 mediated expression of IL-11.
Negative_regulation (block) of Gene_expression (expression) of PROK1-PROKR1
2) Confidence 0.40 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0 Pain Relevance 0.06
RCAN1-4 overexpression inhibits PROK1-induced expression of IL-11
Negative_regulation (inhibits) of Gene_expression (overexpression) of PROK1
3) Confidence 0.40 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0.09 Pain Relevance 0
PROK1 induced expression of IL-11 mRNA at 24 h was significantly reduced by co-treatment of tissue explants with a Gq/11 inhibitor (P < 0.05), a calcium chelator (P < 0.01) or an ERK inhibitor (P < 0.01) (Fig. 5B).
Negative_regulation (reduced) of Gene_expression (expression) of PROK1
4) Confidence 0.40 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0 Pain Relevance 0
In endometrial and ovarian carcinoma, it has been shown that PK1 expression is either absent or reduced compared with normal tissue [40,43].
Negative_regulation (reduced) of Neg (absent) Gene_expression (expression) of PK1 associated with reprotox - general 1
5) Confidence 0.34 Published 2007 Journal Trends in Endocrinology and Metabolism Section Body Doc Link PMC2694302 Disease Relevance 1.86 Pain Relevance 0
During follicle maturation, PK1 and VEGF expression are inversely related.
Negative_regulation (related) of Gene_expression (expression) of PK1 in follicle
6) Confidence 0.34 Published 2007 Journal Trends in Endocrinology and Metabolism Section Body Doc Link PMC2694302 Disease Relevance 0.35 Pain Relevance 0.07

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox