INT272438

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Context Info
Confidence 0.63
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 32
Total Number 41
Disease Relevance 15.06
Pain Relevance 1.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (PROK1)
Anatomy Link Frequency
decidua 3
Leydig cells 2
endometrium 2
follicle 2
cytotrophoblast 2
PROK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 62 96.64 Very High Very High Very High
Inflammatory response 31 84.56 Quite High
cytokine 50 82.36 Quite High
Intracerebroventricular 31 80.44 Quite High
Pain 41 78.20 Quite High
IPN 31 78.20 Quite High
Central nervous system 31 69.12 Quite High
antagonist 62 67.36 Quite High
metalloproteinase 20 54.84 Quite High
Kinase C 31 34.36 Quite Low
Disease Link Frequency Relevance Heat
Polycystic Ovary Syndrome 124 99.84 Very High Very High Very High
Hyperplasia 134 99.80 Very High Very High Very High
Reprotox - General 1 155 99.50 Very High Very High Very High
Cancer 217 99.36 Very High Very High Very High
Endometriosis (extended) 41 98.52 Very High Very High Very High
INFLAMMATION 93 96.64 Very High Very High Very High
Congenital Anomalies 31 96.56 Very High Very High Very High
Targeted Disruption 186 95.32 Very High Very High Very High
Hypoxia 155 95.08 Very High Very High Very High
Frailty 62 93.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Treatment of PROKR1 Ishikawa cells with 40 nM PROK1 had no effect on expression levels of IL-11R?
Gene_expression (Treatment) of PROK1
1) Confidence 0.63 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0.08 Pain Relevance 0
PROK1 induced expression of IL-11 mRNA at 24 h was significantly reduced by co-treatment of tissue explants with a Gq/11 inhibitor (P < 0.05), a calcium chelator (P < 0.01) or an ERK inhibitor (P < 0.01) (Fig. 5B).
Gene_expression (expression) of PROK1
2) Confidence 0.63 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0 Pain Relevance 0
RCAN1-4 overexpression inhibits PROK1-induced expression of IL-11
Gene_expression (expression) of PROK1
3) Confidence 0.63 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0.09 Pain Relevance 0
RCAN1-4 overexpression inhibits PROK1-induced expression of IL-11
Gene_expression (overexpression) of PROK1
4) Confidence 0.63 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0.09 Pain Relevance 0
Here, we have shown that RCAN1-4 is temporally regulated in a reciprocal manner to expression of IL-11 by PROK1–PROKR1.
Gene_expression (expression) of PROK1-PROKR1
5) Confidence 0.63 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0 Pain Relevance 0
Moreover, using a specific inhibitor, INCA-6, which is known to block the interaction between calcineurin and NFAT (Roehrl et al., 2004), we have shown that inhibiting NFAT signalling can block PROK1-PROKR1 mediated expression of IL-11.
Gene_expression (expression) of PROK1-PROKR1
6) Confidence 0.63 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0 Pain Relevance 0.06
Although expression of PK1 and PK2, the latter at considerably lower levels, has been demonstrated in third trimester placentae, neither cellular localization nor receptor expression has been studied [2,6,20,50].
Gene_expression (expression) of PK1
7) Confidence 0.61 Published 2007 Journal Trends in Endocrinology and Metabolism Section Body Doc Link PMC2694302 Disease Relevance 0.11 Pain Relevance 0
However, factors such as human chorionic gonadotropin [43] and progesterone [39], which are known to regulate PK1 expression, are also expressed during this period and they might therefore participate in PK1 regulation.
Gene_expression (expression) of PK1
8) Confidence 0.61 Published 2007 Journal Trends in Endocrinology and Metabolism Section Body Doc Link PMC2694302 Disease Relevance 0.33 Pain Relevance 0
However, VEGF and PK1 are both expressed from six weeks of gestation in fetal Hofbauer cells in placental villous mesenchyme.
Gene_expression (expressed) of PK1 in mesenchyme
9) Confidence 0.61 Published 2007 Journal Trends in Endocrinology and Metabolism Section Body Doc Link PMC2694302 Disease Relevance 0.06 Pain Relevance 0
In primordial and primary follicles, there is high expression of PK1 in granulosa cells but no VEGF expression.
Gene_expression (expression) of PK1 in granulosa cells
10) Confidence 0.61 Published 2007 Journal Trends in Endocrinology and Metabolism Section Body Doc Link PMC2694302 Disease Relevance 0.33 Pain Relevance 0.06
PK1, but not PK2, PKR1 or PKR2, expression peaks during the midluteal ‘window of implantation’, with immunolocalization to endometrial glandular epithelium, stromal and endothelial cells, and myometrial vascular endothelium as well as smooth muscle [39,43,44].
Gene_expression (expression) of PK1 in smooth muscle
11) Confidence 0.61 Published 2007 Journal Trends in Endocrinology and Metabolism Section Body Doc Link PMC2694302 Disease Relevance 0.52 Pain Relevance 0
In the normal ovary, PK1 is expressed in a dynamic way in elements of the sex cord–stroma lineage [40], whereas PK2 expression is not detectable [21].
Gene_expression (expressed) of PK1 in ovary
12) Confidence 0.61 Published 2007 Journal Trends in Endocrinology and Metabolism Section Body Doc Link PMC2694302 Disease Relevance 0.38 Pain Relevance 0.07
In the testis, PK1 is predominantly expressed in testosterone-producing Leydig cells, whereas PK2 is restricted to primary spermatocytes [8,20].
Gene_expression (expressed) of PK1 in Leydig cells
13) Confidence 0.61 Published 2007 Journal Trends in Endocrinology and Metabolism Section Body Doc Link PMC2694302 Disease Relevance 0.64 Pain Relevance 0.19
The strong expression of PK1 by the syncytiotrophoblast, which is the endocrine component of the placenta, suggests that PK1 expression might be associated with a degree of trophoblast differentiation, and it has been hypothesized that PK1 might be a novel placental growth factor [23].
Gene_expression (expression) of PK1 in placenta
14) Confidence 0.61 Published 2007 Journal Trends in Endocrinology and Metabolism Section Body Doc Link PMC2694302 Disease Relevance 0.38 Pain Relevance 0
PK2 is expressed in the bone marrow, as well as in peripheral blood cells, particularly in monocytes, neutrophils and dendritic cells [25], whereas PK1 is expressed in B and T cells, and in inflamed tissues [24].
Gene_expression (expressed) of PK1 in dendritic cells
15) Confidence 0.61 Published 2007 Journal Trends in Endocrinology and Metabolism Section Body Doc Link PMC2694302 Disease Relevance 0.17 Pain Relevance 0.03
In the non-pregnant uterus, PK1 is expressed in the glandular epithelium, as well as in the endothelial and stromal cells of the endometrium, predominantly in the functional layer [39].
Gene_expression (expressed) of PK1 in stromal cells
16) Confidence 0.61 Published 2007 Journal Trends in Endocrinology and Metabolism Section Body Doc Link PMC2694302 Disease Relevance 0 Pain Relevance 0
During follicle maturation, PK1 and VEGF expression are inversely related.
Gene_expression (expression) of PK1 in follicle
17) Confidence 0.61 Published 2007 Journal Trends in Endocrinology and Metabolism Section Body Doc Link PMC2694302 Disease Relevance 0.35 Pain Relevance 0.07
Maturing secondary follicles maintain strong PK1 expression and weak to moderate VEGF expression.
Gene_expression (expression) of PK1 in follicles
18) Confidence 0.61 Published 2007 Journal Trends in Endocrinology and Metabolism Section Body Doc Link PMC2694302 Disease Relevance 0.31 Pain Relevance 0.06
The expression of PK1 and PKR1 peaks in the trophoblast between 8–10 weeks of gestation, with PK1 being localized to the syncytiotrophoblast, minimal expression in the cytotrophoblast and no expression in the extravillous trophoblast [23].
Gene_expression (expression) of PK1 in cytotrophoblast
19) Confidence 0.61 Published 2007 Journal Trends in Endocrinology and Metabolism Section Body Doc Link PMC2694302 Disease Relevance 0.25 Pain Relevance 0
However, in the antral follicle, PK1 is expressed at low levels in theca cells, whereas VEGF expression is very strong in granulosa cells and moderate in theca cells.
Gene_expression (expressed) of PK1 in theca cells
20) Confidence 0.61 Published 2007 Journal Trends in Endocrinology and Metabolism Section Body Doc Link PMC2694302 Disease Relevance 0.29 Pain Relevance 0.06

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