INT272459

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Context Info
Confidence 0.47
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.55
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mRNA binding (Celf1) mRNA processing (Celf1) RNA binding (Celf1)
nucleus (Celf1) cytoplasm (Celf1)
Anatomy Link Frequency
muscle cells 2
myotubes 2
Celf1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 2 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
Kinase C 2 5.00 Very Low Very Low Very Low
spastic colon 1 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Myotonic Dystrophy 30 75.00 Quite High
Disease 26 64.56 Quite High
Cataract 11 59.16 Quite High
Arrhythmias 2 Under Development 3 58.72 Quite High
Hypopituitarism 11 57.60 Quite High
Frailty 10 57.20 Quite High
Targeted Disruption 27 56.16 Quite High
Stress 1 17.52 Low Low
Toxicity 18 5.00 Very Low Very Low Very Low
Myotonia 14 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In DM1 myoblasts, CUGBP1 is hyperphosphorylated by Akt; whereas in DM1 myotubes CUGBP1 phosphorylation by cyclinD3/cdk4 is reduced due to low levels of cytoplasmic cyclin D3 [68].
Negative_regulation (reduced) of Phosphorylation (phosphorylation) of CUGBP1 in myotubes
1) Confidence 0.47 Published 2010 Journal Current Genomics Section Body Doc Link PMC2874224 Disease Relevance 0.12 Pain Relevance 0
Mutant DMPK-mediated effect on subcellular localization, and defective phosphorylation of cytoplasmic CUG-BP1, have additionally been linked to defective translation of p21 and MEF2A in DM1, possibly explaining delayed differentiation of DM1 muscle cells.
Negative_regulation (defective) of Phosphorylation (phosphorylation) of CUG-BP1 in muscle cells
2) Confidence 0.18 Published 2008 Journal Current Genomics Section Abstract Doc Link PMC2694559 Disease Relevance 0.43 Pain Relevance 0

General Comments

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