INT272460

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Context Info
Confidence 0.11
First Reported 2008
Last Reported 2008
Negated 0
Speculated 1
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.41
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Tpt1) extracellular space (Tpt1) transcription factor binding (Tpt1)
cytoplasm (Tpt1)
Anatomy Link Frequency
muscle cells 2
Tpt1 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 2 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Myotonic Dystrophy 8 75.00 Quite High
Cataract 4 55.84 Quite High
Arrhythmias 2 Under Development 1 55.40 Quite High
Hypopituitarism 11 54.28 Quite High
Frailty 3 53.88 Quite High
Disease 13 5.00 Very Low Very Low Very Low
Targeted Disruption 8 5.00 Very Low Very Low Very Low
Toxicity 2 5.00 Very Low Very Low Very Low
Arrhythmia Under Development 2 5.00 Very Low Very Low Very Low
Ataxia 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mutant DMPK-mediated effect on subcellular localization, and defective phosphorylation of cytoplasmic CUG-BP1, have additionally been linked to defective translation of p21 and MEF2A in DM1, possibly explaining delayed differentiation of DM1 muscle cells.
Spec (possibly) Negative_regulation (defective) of Localization (translation) of p21 in muscle cells
1) Confidence 0.11 Published 2008 Journal Current Genomics Section Abstract Doc Link PMC2694559 Disease Relevance 0.41 Pain Relevance 0

General Comments

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