INT272462

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Context Info
Confidence 0.63
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.21
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Clcn1) transmembrane transport (Clcn1)
Anatomy Link Frequency
myoblasts 1
CLC 1
Clcn1 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 5 20.76 Low Low
imagery 4 5.00 Very Low Very Low Very Low
abdominal pain 2 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
Migraine 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
anticonvulsant 1 5.00 Very Low Very Low Very Low
addiction 1 5.00 Very Low Very Low Very Low
complementary and alternative medicine 1 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypopituitarism 32 98.68 Very High Very High Very High
Adverse Drug Reaction 53 93.80 High High
Disease 32 82.56 Quite High
Cataract 10 82.36 Quite High
Targeted Disruption 22 73.28 Quite High
Insulin Resistance 2 71.40 Quite High
Arrhythmia Under Development 7 70.48 Quite High
Myotonic Dystrophy 18 50.00 Quite Low
Frailty 16 50.00 Quite Low
Anxiety Disorder 4 25.84 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since CLCN1 mRNA expression in cultured myoblasts is ?
Transcription (expression) of CLCN1 in myoblasts
1) Confidence 0.63 Published 2010 Journal Current Chemical Genomics Section Body Doc Link PMC2874217 Disease Relevance 0.24 Pain Relevance 0
Myotonia has been attributed to reduced expression of Clcn1 due to the combined effects of a decrease in transcription from the Clcn1 gene and inclusion of alternative exon 7a, which includes a TGA stop codon that triggers non-sense mediated decay [76].
Transcription (transcription) of Clcn1 associated with hypopituitarism
2) Confidence 0.52 Published 2008 Journal Current Genomics Section Body Doc Link PMC2694559 Disease Relevance 0.25 Pain Relevance 0
More recently, the generation of a Mbnl2-deficient mouse also displaying myotonia, skeletal muscle pathology consistent with human DM, and reduced expression of CLC-1 mRNA in skeletal muscle, suggests that depletion of MBNL2 might also contribute to the human DM pathogenesis [64].
Transcription (expression) of CLC-1 in CLC associated with hypopituitarism
3) Confidence 0.50 Published 2008 Journal Current Genomics Section Body Doc Link PMC2694559 Disease Relevance 0.56 Pain Relevance 0
Consumers' descriptions of their NHP-related ADR experiences and reporting behaviours highlight several issues related to the current safety monitoring system.
Transcription (descriptions) of NHP-related ADR
4) Confidence 0.30 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2847952 Disease Relevance 0.16 Pain Relevance 0

General Comments

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