INT272478

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Context Info
Confidence 0.49
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 0.36
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mRNA binding (Celf1) mRNA processing (Celf1) RNA binding (Celf1)
nucleus (Celf1) cytoplasm (Celf1)
Anatomy Link Frequency
myoblasts 2
Celf1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 6 5.00 Very Low Very Low Very Low
Central nervous system 6 5.00 Very Low Very Low Very Low
spastic colon 3 5.00 Very Low Very Low Very Low
depression 3 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
Kinase C 2 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 52 71.68 Quite High
Targeted Disruption 65 62.72 Quite High
Myotonic Dystrophy 74 50.00 Quite Low
Stress 3 24.08 Low Low
Toxicity 50 5.00 Very Low Very Low Very Low
Myotonia 42 5.00 Very Low Very Low Very Low
Congenital Anomalies 33 5.00 Very Low Very Low Very Low
Cataract 25 5.00 Very Low Very Low Very Low
Frailty 24 5.00 Very Low Very Low Very Low
Aging 15 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
During DM1 myogenesis, phosphorylation of CUGBP1 and CUGBP1 interactions with its RNA targets are altered.
Regulation (altered) of Phosphorylation (phosphorylation) of CUGBP1
1) Confidence 0.49 Published 2010 Journal Current Genomics Section Body Doc Link PMC2874224 Disease Relevance 0.12 Pain Relevance 0
These changes of CUGBP1 phosphorylation in DM1 myogenesis lead to the increase of cyclin D1 in DM1 myoblasts and to the reduction p21 in DM1 myotubes [68] (Fig. 7).
Regulation (changes) of Phosphorylation (phosphorylation) of CUGBP1 in myoblasts
2) Confidence 0.36 Published 2010 Journal Current Genomics Section Body Doc Link PMC2874224 Disease Relevance 0.12 Pain Relevance 0
During DM1 myogenesis, phosphorylation of CUGBP1 and CUGBP1 interactions with its RNA targets are altered.
Regulation (altered) of Phosphorylation (phosphorylation) of CUGBP1
3) Confidence 0.36 Published 2010 Journal Current Genomics Section Body Doc Link PMC2874224 Disease Relevance 0.12 Pain Relevance 0
In a recent paper Salisbury and coworkers [91] showed that two key phosphorylation events in CUG-BP1 were mis-regulated during DM1 myogenesis.
Regulation (regulated) of Phosphorylation (phosphorylation) of CUG-BP1
4) Confidence 0.26 Published 2008 Journal Current Genomics Section Body Doc Link PMC2694559 Disease Relevance 0 Pain Relevance 0

General Comments

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